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Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

View ORCID ProfileLouise O Downs, David Smith, Sheila F Lumley, Meha Patel, Anna L McNaughton, Jolynne Mokaya, M Azim Ansari, Hizni Salih, Kinga A Várnai, Oliver Freeman, Sarah Cripps, Jane Phillips, Jane Collier, Kerrie Woods, Keith Channon, Jim Davies, Eleanor Barnes, Katie Jeffery, Philippa C Matthews
doi: https://doi.org/10.1101/494500
Louise O Downs
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UKNuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
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  • ORCID record for Louise O Downs
David Smith
Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UKNational Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU
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Sheila F Lumley
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UKNuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
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Meha Patel
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
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Anna L McNaughton
Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
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Jolynne Mokaya
Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
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M Azim Ansari
Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
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Hizni Salih
Oxford NIHR Biomedical Research Centre Clinical Informatics Group, Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, UK
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Kinga A Várnai
National Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU
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Oliver Freeman
Oxford NIHR Biomedical Research Centre Clinical Informatics Group, Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, UK
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Sarah Cripps
Pharmacy Department, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
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Jane Phillips
Department of Hepatology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
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Jane Collier
Department of Hepatology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
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Kerrie Woods
National Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU
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Keith Channon
National Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU
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Jim Davies
Oxford NIHR Biomedical Research Centre Clinical Informatics Group, Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, UK
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Eleanor Barnes
Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UKNational Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DUDepartment of Hepatology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
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Katie Jeffery
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
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Philippa C Matthews
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UKNuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UKNational Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU
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  • For correspondence: philippa.matthews@ndm.ox.ac.uk
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Article Information

doi 
https://doi.org/10.1101/494500
History 
  • March 26, 2019.

Article Versions

  • Version 1 (December 13, 2018 - 19:30).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Louise O Downs1,2*,
  2. David Smith2,3*,
  3. Sheila F Lumley1,2,
  4. Meha Patel1,
  5. Anna L McNaughton2,
  6. Jolynne Mokaya2,
  7. M Azim Ansari2,
  8. Hizni Salih4,
  9. Kinga A Várnai3,
  10. Oliver Freeman4,
  11. Sarah Cripps5,
  12. Jane Phillips6,
  13. Jane Collier6,
  14. Kerrie Woods3,
  15. Keith Channon3,
  16. Jim Davies4,
  17. Eleanor Barnes2,3,6,
  18. Katie Jeffery1 and
  19. Philippa C Matthews1,2,3,#
  1. 1Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
  2. 2Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
  3. 3National Institutes of Health Research Health Informatics Collaborative, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU
  4. 4Oxford NIHR Biomedical Research Centre Clinical Informatics Group, Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford OX3 7LF, UK
  5. 5Pharmacy Department, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
  6. 6Department of Hepatology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
  1. ↵#CORRESPONDING AUTHOR Email:
    philippa.matthews{at}ndm.ox.ac.uk Address:
    Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK Telephone:
    0044 1865 271973
  1. ↵* These two authors contributed equally

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Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection
Louise O Downs, David Smith, Sheila F Lumley, Meha Patel, Anna L McNaughton, Jolynne Mokaya, M Azim Ansari, Hizni Salih, Kinga A Várnai, Oliver Freeman, Sarah Cripps, Jane Phillips, Jane Collier, Kerrie Woods, Keith Channon, Jim Davies, Eleanor Barnes, Katie Jeffery, Philippa C Matthews
bioRxiv 494500; doi: https://doi.org/10.1101/494500
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Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection
Louise O Downs, David Smith, Sheila F Lumley, Meha Patel, Anna L McNaughton, Jolynne Mokaya, M Azim Ansari, Hizni Salih, Kinga A Várnai, Oliver Freeman, Sarah Cripps, Jane Phillips, Jane Collier, Kerrie Woods, Keith Channon, Jim Davies, Eleanor Barnes, Katie Jeffery, Philippa C Matthews
bioRxiv 494500; doi: https://doi.org/10.1101/494500

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