Swapping Birth and Death: Symmetries and Transformations in Phylodynamic Models

Abstract

Stochastic birth–death models provide the foundation for studying and simulating evolutionary trees in phylodynamics. A curious feature of such models is that they exhibit fundamental symmetries when the birth and death rates are interchanged. In this paper, we explain and formally derive these transformational symmetries. We also show that these transformational symmetries (encoded in algebraic identities) are preserved even when taxa at the present are sampled with some probability. However, these extended symmetries require the death rate parameter to sometimes take a negative value. In the last part of this paper, we describe the relevance of these transformations and their application to computational phylodynamics, particularly to maximum likelihood and Bayesian inference methods, as well as to model selection. Phylodynamics, phylogenetics, speciation-extinction models, birth-death models, algebraic symmetries, maximum likelihood, Bayesian inference