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International travelers and genomics uncover a ‘hidden’ Zika outbreak

Nathan D. Grubaugh, Sharada Saraf, Karthik Gangavarapu, Alexander Watts, Amanda L. Tan, Rachel J. Oidtman, Jason T. Ladner, Glenn Oliveira, Nathaniel L. Matteson, Moritz U.G. Kraemer, Chantal B.F. Vogels, Aaron Hentoff, Deepit Bhatia, Danielle Stanek, Blake Scott, Vanessa Landis, Ian Stryker, Marshall R. Cone, Edgar W. Kopp IV, Andrew C. Cannons, Lea Heberlein-Larson, Stephen White, Leah D. Gillis, Michael J. Ricciardi, Jaclyn Kwal, Paola K. Lichtenberger, Diogo M. Magnani, David I. Watkins, Gustavo Palacios, Davidson H. Hamer, for the GeoSentinel Surveillance Network, Lauren M. Gardner, T. Alex Perkins, Guy Baele, Kamran Khan, Andrea Morrison, Sharon Isern, Scott F. Michael, Kristian G. Andersen
doi: https://doi.org/10.1101/496901
Nathan D. Grubaugh
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Sharada Saraf
2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Karthik Gangavarapu
2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Alexander Watts
3Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON M5B 1T8, Canada
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Amanda L. Tan
4Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA
5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
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Rachel J. Oidtman
6Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA
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Jason T. Ladner
7Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
8Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA
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Glenn Oliveira
2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Nathaniel L. Matteson
2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Moritz U.G. Kraemer
9Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
10Boston Children’s Hospital, Boston, MA 02115, USA
11Harvard Medical School, Boston, MA 02115, USA
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Chantal B.F. Vogels
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
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Aaron Hentoff
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
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Deepit Bhatia
3Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON M5B 1T8, Canada
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Danielle Stanek
12Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA
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Blake Scott
12Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA
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Vanessa Landis
12Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA
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Ian Stryker
5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
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Marshall R. Cone
5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
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Edgar W. Kopp IV
5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
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Andrew C. Cannons
5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
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Lea Heberlein-Larson
5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
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Stephen White
13Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA
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Leah D. Gillis
13Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA
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Michael J. Ricciardi
14Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Jaclyn Kwal
14Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Paola K. Lichtenberger
14Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Diogo M. Magnani
14Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
15MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA
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David I. Watkins
14Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Gustavo Palacios
7Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
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Davidson H. Hamer
16Department of Global Health, Boston University School of Public Health, Boston, MA 02118, USA
17Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA 02118, USA
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Lauren M. Gardner
18School of Civil and Environmental Engineering, UNSW Sydney, Sydney, New South Wales 2052 Australia
19Department of Civil Engineering, Johns Hopkins University, Baltimore, MD 21287, USA
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T. Alex Perkins
6Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA
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Guy Baele
20Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
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Kamran Khan
3Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON M5B 1T8, Canada
21Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON M5B 1T8, Canada
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Andrea Morrison
12Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA
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Sharon Isern
4Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA
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Scott F. Michael
4Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA
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Kristian G. Andersen
2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
22Scripps Research Translational Institute, La Jolla, California 92037, USA
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Article Information

doi 
https://doi.org/10.1101/496901
History 
  • December 14, 2018.

Article Versions

  • Version 1 (December 14, 2018 - 10:12).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. Nathan D. Grubaugh1,2,*,
  2. Sharada Saraf2,*,
  3. Karthik Gangavarapu2,*,
  4. Alexander Watts3,
  5. Amanda L. Tan4,5,
  6. Rachel J. Oidtman6,
  7. Jason T. Ladner7,8,
  8. Glenn Oliveira2,
  9. Nathaniel L. Matteson2,
  10. Moritz U.G. Kraemer9,10,11,
  11. Chantal B.F. Vogels1,
  12. Aaron Hentoff1,
  13. Deepit Bhatia3,
  14. Danielle Stanek12,
  15. Blake Scott12,
  16. Vanessa Landis12,
  17. Ian Stryker5,
  18. Marshall R. Cone5,
  19. Edgar W. Kopp IV5,
  20. Andrew C. Cannons5,
  21. Lea Heberlein-Larson5,
  22. Stephen White13,
  23. Leah D. Gillis13,
  24. Michael J. Ricciardi14,
  25. Jaclyn Kwal14,
  26. Paola K. Lichtenberger14,
  27. Diogo M. Magnani14,15,
  28. David I. Watkins14,
  29. Gustavo Palacios7,
  30. Davidson H. Hamer16,17,
  31. for the GeoSentinel Surveillance Network,
  32. Lauren M. Gardner18,19,
  33. T. Alex Perkins6,
  34. Guy Baele20,
  35. Kamran Khan3,21,
  36. Andrea Morrison12,§,
  37. Sharon Isern4,§,
  38. Scott F. Michael4,§ and
  39. Kristian G. Andersen2,22,§
  1. 1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  2. 2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
  3. 3Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON M5B 1T8, Canada
  4. 4Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA
  5. 5Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA
  6. 6Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA
  7. 7Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
  8. 8Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA
  9. 9Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
  10. 10Boston Children’s Hospital, Boston, MA 02115, USA
  11. 11Harvard Medical School, Boston, MA 02115, USA
  12. 12Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA
  13. 13Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA
  14. 14Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  15. 15MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA
  16. 16Department of Global Health, Boston University School of Public Health, Boston, MA 02118, USA
  17. 17Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA 02118, USA
  18. 18School of Civil and Environmental Engineering, UNSW Sydney, Sydney, New South Wales 2052 Australia
  19. 19Department of Civil Engineering, Johns Hopkins University, Baltimore, MD 21287, USA
  20. 20Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
  21. 21Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON M5B 1T8, Canada
  22. 22Scripps Research Translational Institute, La Jolla, California 92037, USA
  1. Correspondence and requests for materials should be addressed to N.D.G. (email: nathan.grubaugh{at}yale.edu) or S.F.M. (email: smichael{at}fgcu.edu)
  1. ↵* These authors contributed equally to this work.

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International travelers and genomics uncover a ‘hidden’ Zika outbreak
Nathan D. Grubaugh, Sharada Saraf, Karthik Gangavarapu, Alexander Watts, Amanda L. Tan, Rachel J. Oidtman, Jason T. Ladner, Glenn Oliveira, Nathaniel L. Matteson, Moritz U.G. Kraemer, Chantal B.F. Vogels, Aaron Hentoff, Deepit Bhatia, Danielle Stanek, Blake Scott, Vanessa Landis, Ian Stryker, Marshall R. Cone, Edgar W. Kopp IV, Andrew C. Cannons, Lea Heberlein-Larson, Stephen White, Leah D. Gillis, Michael J. Ricciardi, Jaclyn Kwal, Paola K. Lichtenberger, Diogo M. Magnani, David I. Watkins, Gustavo Palacios, Davidson H. Hamer, for the GeoSentinel Surveillance Network, Lauren M. Gardner, T. Alex Perkins, Guy Baele, Kamran Khan, Andrea Morrison, Sharon Isern, Scott F. Michael, Kristian G. Andersen
bioRxiv 496901; doi: https://doi.org/10.1101/496901
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International travelers and genomics uncover a ‘hidden’ Zika outbreak
Nathan D. Grubaugh, Sharada Saraf, Karthik Gangavarapu, Alexander Watts, Amanda L. Tan, Rachel J. Oidtman, Jason T. Ladner, Glenn Oliveira, Nathaniel L. Matteson, Moritz U.G. Kraemer, Chantal B.F. Vogels, Aaron Hentoff, Deepit Bhatia, Danielle Stanek, Blake Scott, Vanessa Landis, Ian Stryker, Marshall R. Cone, Edgar W. Kopp IV, Andrew C. Cannons, Lea Heberlein-Larson, Stephen White, Leah D. Gillis, Michael J. Ricciardi, Jaclyn Kwal, Paola K. Lichtenberger, Diogo M. Magnani, David I. Watkins, Gustavo Palacios, Davidson H. Hamer, for the GeoSentinel Surveillance Network, Lauren M. Gardner, T. Alex Perkins, Guy Baele, Kamran Khan, Andrea Morrison, Sharon Isern, Scott F. Michael, Kristian G. Andersen
bioRxiv 496901; doi: https://doi.org/10.1101/496901

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