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Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis

Sashaina E. Fanibunda, Sukrita Deb, Babukrishna Maniyadat, Samir Gupta, Noelia Weisstaub, Jay A. Gingrich, Ashok D.B. Vaidya, Ullas Kolthur-Seetharam, Vidita A. Vaidya
doi: https://doi.org/10.1101/497982
Sashaina E. Fanibunda
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
2Medical Research Centre, Kasturba Health Society, Mumbai, India.
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Sukrita Deb
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
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Babukrishna Maniyadat
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
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Samir Gupta
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
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Noelia Weisstaub
3Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina.
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Jay A. Gingrich
4Department of Psychiatry, Columbia University, New York.
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Ashok D.B. Vaidya
2Medical Research Centre, Kasturba Health Society, Mumbai, India.
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Ullas Kolthur-Seetharam
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
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  • For correspondence: vvaidya@tifr.res.in ullas@tifr.res.in
Vidita A. Vaidya
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
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  • For correspondence: vvaidya@tifr.res.in ullas@tifr.res.in
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Article Information

doi 
https://doi.org/10.1101/497982
History 
  • December 16, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Sashaina E. Fanibunda1,2,
  2. Sukrita Deb1,
  3. Babukrishna Maniyadat1,
  4. Samir Gupta1,
  5. Noelia Weisstaub3,
  6. Jay A. Gingrich4,
  7. Ashok D.B. Vaidya2,
  8. Ullas Kolthur-Seetharam1,* and
  9. Vidita A. Vaidya1,*
  1. 1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
  2. 2Medical Research Centre, Kasturba Health Society, Mumbai, India.
  3. 3Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina.
  4. 4Department of Psychiatry, Columbia University, New York.
  1. ↵*Address correspondence to: Dr. Vidita A. Vaidya Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India Telephone Number: +91 22 22782608 Fax Number: + 91-22 22804610 E-mail: vvaidya{at}tifr.res.in; Dr. Ullas Kolthur-Seetharam Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India Telephone Number: +91 22 22782721 Fax Number: + 91-22 22804610 E-mail: ullas{at}tifr.res.in
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Posted December 16, 2018.
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Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis
Sashaina E. Fanibunda, Sukrita Deb, Babukrishna Maniyadat, Samir Gupta, Noelia Weisstaub, Jay A. Gingrich, Ashok D.B. Vaidya, Ullas Kolthur-Seetharam, Vidita A. Vaidya
bioRxiv 497982; doi: https://doi.org/10.1101/497982
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Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis
Sashaina E. Fanibunda, Sukrita Deb, Babukrishna Maniyadat, Samir Gupta, Noelia Weisstaub, Jay A. Gingrich, Ashok D.B. Vaidya, Ullas Kolthur-Seetharam, Vidita A. Vaidya
bioRxiv 497982; doi: https://doi.org/10.1101/497982

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