AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathy

Jean-Baptiste Dupont; Jianjun Guo; Michael W. Lawlor; Robert W. Grange; John T. Gray; Ana Buj-Bello; Martin K. Childers; David L. Mack

doi:10.1101/499384

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AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathy

Jean-Baptiste Dupont, Jianjun Guo, Michael W. Lawlor, Robert W. Grange, John T. Gray, Ana Buj-Bello, Martin K. Childers, David L. Mack

doi: https://doi.org/10.1101/499384

Jean-Baptiste Dupont

1Departments of Rehabilitation Medicine, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

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Jianjun Guo

3Audentes Therapeutics, San Francisco, CA 94108, USA.

7Present address: Clinical NGS Group, Thermo Fisher Scientific, South San Francisco, CA 94080, USA.

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Michael W. Lawlor

4Department of Pathology and Laboratory Medicine and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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Robert W. Grange

5Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.

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John T. Gray

3Audentes Therapeutics, San Francisco, CA 94108, USA.

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Ana Buj-Bello

6Généthon, INSERM UMR S951, Université Evry Val-d’Essone, Université Paris-Saclay, 91000 Evry, France.

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Martin K. Childers

1Departments of Rehabilitation Medicine, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

8Present address: AskBio, Chapel Hill, NC 27514, USA.

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David L. Mack

1Departments of Rehabilitation Medicine, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

2Department of Bioengineering, University of Washington, Seattle, WA 98109, USA.

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For correspondence: dmack21@uw.edu

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Posted December 17, 2018.

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AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathy

Jean-Baptiste Dupont, Jianjun Guo, Michael W. Lawlor, Robert W. Grange, John T. Gray, Ana Buj-Bello, Martin K. Childers, David L. Mack

bioRxiv 499384; doi: https://doi.org/10.1101/499384

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AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathy

Jean-Baptiste Dupont, Jianjun Guo, Michael W. Lawlor, Robert W. Grange, John T. Gray, Ana Buj-Bello, Martin K. Childers, David L. Mack

bioRxiv 499384; doi: https://doi.org/10.1101/499384

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