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The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions
Anne-Laure Mahul-Mellier, Melek Firat Altay, Johannes Burtscher, Niran Maharjan, Nadine Ait-Bouziad, Anass Chiki, Siv Vingill, Richard Wade-Martins, Janice Holton, Catherine Strand, Caroline Haikal, Jia-Yi Li, Romain Hamelin, Marie Croisier, Graham Knott, Georges Mairet-Coello, Laura Weerens, Anne Michel, Patrick Downey, Martin Citron, Hilal A. Lashuel
doi: https://doi.org/10.1101/500058
Anne-Laure Mahul-Mellier
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Melek Firat Altay
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Johannes Burtscher
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Niran Maharjan
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Nadine Ait-Bouziad
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Anass Chiki
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Siv Vingill
2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
Richard Wade-Martins
2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
Janice Holton
3Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
Catherine Strand
3Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
Caroline Haikal
4Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden
Jia-Yi Li
4Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden
5Institute of Health Sciences, China Medical University, 110122 Shenyang, China
Romain Hamelin
6Proteomic Core Facility and Technology Platform, EPFL, Lausanne 1015, Switzerland
Marie Croisier
7BioEM Core Facility and Technology Platform, EPFL, Lausanne 1015, Switzerland
Graham Knott
7BioEM Core Facility and Technology Platform, EPFL, Lausanne 1015, Switzerland
Georges Mairet-Coello
8UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l’Alleud, Belgium
Laura Weerens
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
8UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l’Alleud, Belgium
Anne Michel
8UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l’Alleud, Belgium
Patrick Downey
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Martin Citron
8UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l’Alleud, Belgium
Hilal A. Lashuel
1Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Posted December 19, 2018.
The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions
Anne-Laure Mahul-Mellier, Melek Firat Altay, Johannes Burtscher, Niran Maharjan, Nadine Ait-Bouziad, Anass Chiki, Siv Vingill, Richard Wade-Martins, Janice Holton, Catherine Strand, Caroline Haikal, Jia-Yi Li, Romain Hamelin, Marie Croisier, Graham Knott, Georges Mairet-Coello, Laura Weerens, Anne Michel, Patrick Downey, Martin Citron, Hilal A. Lashuel
bioRxiv 500058; doi: https://doi.org/10.1101/500058
The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions
Anne-Laure Mahul-Mellier, Melek Firat Altay, Johannes Burtscher, Niran Maharjan, Nadine Ait-Bouziad, Anass Chiki, Siv Vingill, Richard Wade-Martins, Janice Holton, Catherine Strand, Caroline Haikal, Jia-Yi Li, Romain Hamelin, Marie Croisier, Graham Knott, Georges Mairet-Coello, Laura Weerens, Anne Michel, Patrick Downey, Martin Citron, Hilal A. Lashuel
bioRxiv 500058; doi: https://doi.org/10.1101/500058
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