A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe; Sven Stringer; Oleksandr Frei; Maša Umićević Mirkov; Tinca J.C. Polderman; Sophie van der Sluis; Ole A. Andreassen; Benjamin M. Neale; Danielle Posthuma

doi:10.1101/500090

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A global overview of pleiotropy and genetic architecture in complex traits

View ORCID ProfileKyoko Watanabe, Sven Stringer, View ORCID ProfileOleksandr Frei, Maša Umićević Mirkov, View ORCID ProfileTinca J.C. Polderman, View ORCID ProfileSophie van der Sluis, View ORCID ProfileOle A. Andreassen, View ORCID ProfileBenjamin M. Neale, View ORCID ProfileDanielle Posthuma

doi: https://doi.org/10.1101/500090

Kyoko Watanabe

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands

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ORCID record for Kyoko Watanabe

Sven Stringer

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands

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Oleksandr Frei

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Criminal Medicine, University of Oslo, Oslo, Norway

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Maša Umićević Mirkov

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands

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Tinca J.C. Polderman

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands

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ORCID record for Tinca J.C. Polderman

Sophie van der Sluis

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The NetherlandsDepartment of Clinical Genetics, Section of Complex Trait Genetics, Neuroscience Campus Amsterdam, VU Medical Center, Amsterdam, the Netherlands

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Ole A. Andreassen

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Criminal Medicine, University of Oslo, Oslo, NorwayDivision of Mental health and addiction Oslo University hospital, Oslo, Norway

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Benjamin M. Neale

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USAStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA

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Danielle Posthuma

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For correspondence: d.posthuma@vu.nl

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A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe, Sven Stringer, Oleksandr Frei, Maša Umićević Mirkov, Tinca J.C. Polderman, Sophie van der Sluis, Ole A. Andreassen, Benjamin M. Neale, Danielle Posthuma

bioRxiv 500090; doi: https://doi.org/10.1101/500090

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A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe, Sven Stringer, Oleksandr Frei, Maša Umićević Mirkov, Tinca J.C. Polderman, Sophie van der Sluis, Ole A. Andreassen, Benjamin M. Neale, Danielle Posthuma

bioRxiv 500090; doi: https://doi.org/10.1101/500090

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