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SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation

View ORCID ProfileGuilherme B Saturnino, View ORCID ProfileOula Puonti, Jesper D Nielsen, Daria Antonenko, View ORCID ProfileKristoffer H Madsen, View ORCID ProfileAxel Thielscher
doi: https://doi.org/10.1101/500314
Guilherme B Saturnino
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
2Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark
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Oula Puonti
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
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Jesper D Nielsen
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
3Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark
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Daria Antonenko
4Department of Neurology, Universitätsmedizin Greifswald, Greifswald, Germany
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Kristoffer H Madsen
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
3Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark
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Axel Thielscher
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
2Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark
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Abstract

Numerical simulation of the electric fields induced by Non-Invasive Brain Stimulation (NIBS), using realistic anatomical head models has gained interest in recent years for understanding the NIBS effects in individual subjects. Although automated tools for generating the head models and performing the electric field simulations have become available, individualized modelling is still not standard practice in NIBS studies. This is likely partly explained by the lack of robustness and usability of the previously available software tools, and partly by the still developing understanding of the link between physiological effects and electric field distributions in the brain. To facilitate individualized modelling in NIBS, we have introduced the SimNIBS (Simulation of NIBS) software package, providing easy-to-use automated tools for electric field modelling. In this article, we give an overview of the modelling pipeline in SimNIBS 2.1, with step-by-step examples of how to run a simulation. Furthermore, we demonstrate a set of scripts for extracting average electric fields for a group of subjects, and finally demonstrate the accuracy of automated placement of standard electrode montages on the head model. SimNIBS 2.1 is freely available at www.simnibs.org.

Footnotes

  • E-mail: axelt{at}drcmr.dk

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 19, 2018.
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SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation
Guilherme B Saturnino, Oula Puonti, Jesper D Nielsen, Daria Antonenko, Kristoffer H Madsen, Axel Thielscher
bioRxiv 500314; doi: https://doi.org/10.1101/500314
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SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation
Guilherme B Saturnino, Oula Puonti, Jesper D Nielsen, Daria Antonenko, Kristoffer H Madsen, Axel Thielscher
bioRxiv 500314; doi: https://doi.org/10.1101/500314

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