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Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening
Fiona M Behan, View ORCID ProfileFrancesco Iorio, View ORCID ProfileEmanuel Gonçalves, Gabriele Picco, Charlotte M Beaver, Rita Santos, Yanhua Rao, Rizwan Ansari, Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, David Dow, Carolyn Buser-Doepner, Euan A. Stronach, View ORCID ProfileJulio Saez-Rodriguez, Kosuke Yusa, View ORCID ProfileMathew J Garnett
doi: https://doi.org/10.1101/502005
Fiona M Behan
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Francesco Iorio
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
3European Molecular Biology Laboratory – European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SD, UK
Emanuel Gonçalves
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Gabriele Picco
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Charlotte M Beaver
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Rita Santos
4GSK, Target Sciences, Gunnels Wood Road, Stevenage, SG1 2NY, UK and Collegeville, Pennsylvania, 19426–0989, USA
Yanhua Rao
4GSK, Target Sciences, Gunnels Wood Road, Stevenage, SG1 2NY, UK and Collegeville, Pennsylvania, 19426–0989, USA
Rizwan Ansari
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Sarah Harper
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
David Adam Jackson
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Rebecca McRae
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Rachel Pooley
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Piers Wilkinson
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
David Dow
4GSK, Target Sciences, Gunnels Wood Road, Stevenage, SG1 2NY, UK and Collegeville, Pennsylvania, 19426–0989, USA
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Carolyn Buser-Doepner
4GSK, Target Sciences, Gunnels Wood Road, Stevenage, SG1 2NY, UK and Collegeville, Pennsylvania, 19426–0989, USA
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Euan A. Stronach
4GSK, Target Sciences, Gunnels Wood Road, Stevenage, SG1 2NY, UK and Collegeville, Pennsylvania, 19426–0989, USA
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Julio Saez-Rodriguez
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
3European Molecular Biology Laboratory – European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SD, UK
5Faculty of Medicine, Joint Research Centre for Computational Biomedicine, RWTH Aachen University, Aachen 52057, Germany
6Heidelberg University, Heidelberg, Germany
Kosuke Yusa
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Mathew J Garnett
1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Cambridge CB10 1SA, UK
Article usage
Posted December 20, 2018.
Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening
Fiona M Behan, Francesco Iorio, Emanuel Gonçalves, Gabriele Picco, Charlotte M Beaver, Rita Santos, Yanhua Rao, Rizwan Ansari, Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, David Dow, Carolyn Buser-Doepner, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J Garnett
bioRxiv 502005; doi: https://doi.org/10.1101/502005
Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening
Fiona M Behan, Francesco Iorio, Emanuel Gonçalves, Gabriele Picco, Charlotte M Beaver, Rita Santos, Yanhua Rao, Rizwan Ansari, Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, David Dow, Carolyn Buser-Doepner, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J Garnett
bioRxiv 502005; doi: https://doi.org/10.1101/502005
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