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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

Yang Luo, Xinyi Li, Xin Wang, Steven Gazal, Josep Maria Mercader, 23andMe Research Team, SIGMA Type 2 Diabetes Consortium, Benjamin M. Neale, Jose C. Florez, Adam Auton, Alkes L. Price, Hilary K. Finucane, Soumya Raychaudhuri
doi: https://doi.org/10.1101/503144

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doi 
https://doi.org/10.1101/503144
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  • March 18, 2020.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Yang Luo1,2,3,4,5,*,
  2. Xinyi Li1,2,3,4,5,*,
  3. Xin Wang6,
  4. Steven Gazal3,7,
  5. Josep Maria Mercader3,8,
  6. 23andMe Research Team6,
  7. SIGMA Type 2 Diabetes Consortium,
  8. Benjamin M. Neale3,9,
  9. Jose C. Florez3,8,10,
  10. Adam Auton6,
  11. Alkes L. Price3,7,11,
  12. Hilary K. Finucane3,,† and
  13. Soumya Raychaudhuri1,2,3,4,5,12,,†
  1. 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  2. 2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  3. 3Broad Institute of MIT and Harvard, Cambridge, MA, USA
  4. 4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
  5. 5Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  6. 623andMe, Inc., Mountain View, California, USA
  7. 7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  8. 8Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
  9. 9Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  10. 10Department of Medicine, Harvard Medical School, Boston, MA, USA
  11. 11Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  12. 12Arthritis Research UK Centre for Genetics andGenomics, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
  1. ↵†Correspondence should be addressed to H.K.F. (finucane{at}broadinstitute.org) or S.R. (soumya{at}broadinstitute.org).

  1. ↵* These authors contributed equally to this work.

  2. ↵ These authors contributed equally to this work.

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Posted March 18, 2020.
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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
Yang Luo, Xinyi Li, Xin Wang, Steven Gazal, Josep Maria Mercader, 23andMe Research Team, SIGMA Type 2 Diabetes Consortium, Benjamin M. Neale, Jose C. Florez, Adam Auton, Alkes L. Price, Hilary K. Finucane, Soumya Raychaudhuri
bioRxiv 503144; doi: https://doi.org/10.1101/503144
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