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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
View ORCID ProfileYang Luo, Xinyi Li, Xin Wang, Steven Gazal, Josep Maria Mercader, 23andMe Research Team, SIGMA Type 2 Diabetes Consortium, Benjamin M. Neale, Jose C. Florez, Adam Auton, Alkes L. Price, Hilary K. Finucane, Soumya Raychaudhuri
doi: https://doi.org/10.1101/503144
Yang Luo
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
5Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Xinyi Li
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
5Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Xin Wang
623andMe, Inc., Mountain View, California, USA
Steven Gazal
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Josep Maria Mercader
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
8Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
623andMe, Inc., Mountain View, California, USA
Benjamin M. Neale
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Jose C. Florez
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
8Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
10Department of Medicine, Harvard Medical School, Boston, MA, USA
Adam Auton
623andMe, Inc., Mountain View, California, USA
Alkes L. Price
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
11Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Hilary K. Finucane
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
Soumya Raychaudhuri
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
5Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
12Arthritis Research UK Centre for Genetics andGenomics, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
Article usage
Posted March 18, 2020.
Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
Yang Luo, Xinyi Li, Xin Wang, Steven Gazal, Josep Maria Mercader, 23andMe Research Team, SIGMA Type 2 Diabetes Consortium, Benjamin M. Neale, Jose C. Florez, Adam Auton, Alkes L. Price, Hilary K. Finucane, Soumya Raychaudhuri
bioRxiv 503144; doi: https://doi.org/10.1101/503144
Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
Yang Luo, Xinyi Li, Xin Wang, Steven Gazal, Josep Maria Mercader, 23andMe Research Team, SIGMA Type 2 Diabetes Consortium, Benjamin M. Neale, Jose C. Florez, Adam Auton, Alkes L. Price, Hilary K. Finucane, Soumya Raychaudhuri
bioRxiv 503144; doi: https://doi.org/10.1101/503144
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