Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathology

Stefan Grathwohl; Emmanuel Quansah; Nazia Maroof; Jennifer A. Steiner; Liz Spycher; Fethallah Benmansour; Gonzalo Duran-Pacheco; Juliane Siebourg-Polster; Krisztina Oroszlan-Szovik; Helga Remy; Markus Haenggi; Marc Stawiski; Matthias Sehlhausen; Pierre Maliver; Andreas Wolfert; Thomas Emrich; Zachary Madaj; Martha L. Escobar Galvis; Christoph Mueller; Annika Herrmann; Patrik Brundin; Markus Britschgi

doi:10.1101/505164

New Results

Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathology

Stefan Grathwohl, Emmanuel Quansah, Nazia Maroof, Jennifer A. Steiner, Liz Spycher, Fethallah Benmansour, Gonzalo Duran-Pacheco, Juliane Siebourg-Polster, Krisztina Oroszlan-Szovik, Helga Remy, Markus Haenggi, Marc Stawiski, Matthias Sehlhausen, Pierre Maliver, Andreas Wolfert, Thomas Emrich, Zachary Madaj, Martha L. Escobar Galvis, Christoph Mueller, Annika Herrmann, Patrik Brundin, View ORCID ProfileMarkus Britschgi

doi: https://doi.org/10.1101/505164

Stefan Grathwohl

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Emmanuel Quansah

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, USA

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Nazia Maroof

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Jennifer A. Steiner

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, USA

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Liz Spycher

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Fethallah Benmansour

Roche Pharma Research and Early Development, pREDi, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Gonzalo Duran-Pacheco

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Juliane Siebourg-Polster

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Krisztina Oroszlan-Szovik

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Helga Remy

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Markus Haenggi

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Marc Stawiski

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Matthias Sehlhausen

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Pierre Maliver

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Andreas Wolfert

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany

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Thomas Emrich

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany

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Zachary Madaj

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, USA

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Martha L. Escobar Galvis

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, USA

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Christoph Mueller

Institute of Pathology, University of Bern, Murtenstrasse 31, Bern, Switzerland

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Annika Herrmann

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland

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Patrik Brundin

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, USA

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Markus Britschgi

Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, Switzerland