Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis

Sergey D. Stavisky, Francis R. Willett, Brian A Murphy, Paymon Rezaii, William D. Memberg, Jonathan P. Miller, Robert F. Kirsch, Leigh R Hochberg, A. Bolu Ajiboye, Krishna V. Shenoy, Jaimie M. Henderson
doi: https://doi.org/10.1101/505487
Sergey D. Stavisky
Department of Neurosurgery, Stanford University, Stanford, CA, USADepartment of Electrical Engineering, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: sergey.stavisky@stanford.edu
Francis R. Willett
Department of Neurosurgery, Stanford University, Stanford, CA, USADepartment of Electrical Engineering, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian A Murphy
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, FES Center, Rehab. R&D Service, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paymon Rezaii
Department of Neurosurgery, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William D. Memberg
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, FES Center, Rehab. R&D Service, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan P. Miller
Louis Stokes Cleveland Department of Veterans Affairs Medical Center, FES Center, Rehab. R&D Service, Cleveland, Ohio, USADepartment of Neurosurgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert F. Kirsch
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, FES Center, Rehab. R&D Service, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leigh R Hochberg
VA RR&D Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Providence VA Medical Center, Providence, RI, USASchool of Engineering and Carney Institute for Brain Science, Brown University, Providence, RI, USADepartment of Neurology, Harvard Medical School, Boston, MA, USACenter for Neurotechnology and Neurorecovery, Dept. of Neurology, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Bolu Ajiboye
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, FES Center, Rehab. R&D Service, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Krishna V. Shenoy
Department of Electrical Engineering, Stanford University, Stanford, CA, USADepartment of Bioengineering, Stanford University, Stanford, CA, USADepartment of Neurobiology, Stanford University, Stanford, CA, USAHoward Hughes Medical Institute at Stanford University, Stanford, CA, USAWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USABio-X Program, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaimie M. Henderson
Department of Neurosurgery, Stanford University, Stanford, CA, USAWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USABio-X Program, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

ABSTRACT

Speaking is a sensorimotor behavior whose neural basis difficult to study at the resolution of single neurons due to the scarcity of human intracortical measurements and the lack of animal models. We recorded from electrode arrays in the ‘hand knob’ area of motor cortex in people with tetraplegia. Neurons in this area, which have not previously been implicated in speech, modulated during speaking and during nonspeaking movement of the tongue, lips, and jaw. This challenges whether the conventional model of a ‘motor homunculus’ division by major body regions extends to the single-neuron scale. Spoken words and syllables could be decoded from single trials, demonstrating the potential utility of intracortical recordings for brain-computer interfaces (BCIs) to restore speech. Two neural population dynamics features previously reported for arm movements were also present during speaking: a large initial condition-invariant signal, followed by rotatory dynamics. This suggests that common neural dynamical motifs may underlie movement of arm and speech articulators.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted December 30, 2018.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis
Sergey D. Stavisky, Francis R. Willett, Brian A Murphy, Paymon Rezaii, William D. Memberg, Jonathan P. Miller, Robert F. Kirsch, Leigh R Hochberg, A. Bolu Ajiboye, Krishna V. Shenoy, Jaimie M. Henderson
bioRxiv 505487; doi: https://doi.org/10.1101/505487
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis
Sergey D. Stavisky, Francis R. Willett, Brian A Murphy, Paymon Rezaii, William D. Memberg, Jonathan P. Miller, Robert F. Kirsch, Leigh R Hochberg, A. Bolu Ajiboye, Krishna V. Shenoy, Jaimie M. Henderson
bioRxiv 505487; doi: https://doi.org/10.1101/505487

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1641)
  • Biochemistry (2721)
  • Bioengineering (1902)
  • Bioinformatics (10201)
  • Biophysics (4174)
  • Cancer Biology (3202)
  • Cell Biology (4522)
  • Clinical Trials (135)
  • Developmental Biology (2831)
  • Ecology (4447)
  • Epidemiology (2041)
  • Evolutionary Biology (7213)
  • Genetics (5463)
  • Genomics (6793)
  • Immunology (2379)
  • Microbiology (7462)
  • Molecular Biology (2978)
  • Neuroscience (18529)
  • Paleontology (135)
  • Pathology (472)
  • Pharmacology and Toxicology (776)
  • Physiology (1147)
  • Plant Biology (2692)
  • Scientific Communication and Education (679)
  • Synthetic Biology (885)
  • Systems Biology (2840)
  • Zoology (465)