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Inception in visual cortex: in vivo-silico loops reveal most exciting images

View ORCID ProfileEdgar Y. Walke, View ORCID ProfileFabian H. Sinz, Emmanouil Froudarakis, View ORCID ProfilePaul G. Fahey, Taliah Muhammad, View ORCID ProfileAlexander S. Ecker, Erick Cobos, Jacob Reimer, View ORCID ProfileXaq Pitkow, View ORCID ProfileAndreas S. Tolias
doi: https://doi.org/10.1101/506956
Edgar Y. Walke
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
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  • ORCID record for Edgar Y. Walke
  • For correspondence: astolias@bcm.edu eywalker@bcm.edu fabian.sinz@bcm.edu
Fabian H. Sinz
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
5Bernstein Center for Computational Neuroscience, University of Tübingen, Germany
7Institute for Computer Science, University of Tübingen, Germany
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  • ORCID record for Fabian H. Sinz
  • For correspondence: astolias@bcm.edu eywalker@bcm.edu fabian.sinz@bcm.edu
Emmanouil Froudarakis
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
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Paul G. Fahey
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
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Taliah Muhammad
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
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Alexander S. Ecker
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
4Centre for Integrative Neuroscience, University of Tübingen, Germany
5Bernstein Center for Computational Neuroscience, University of Tübingen, Germany
6Institute for Theoretical Physics, University of Tübingen, Germany
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Erick Cobos
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
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Jacob Reimer
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
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Xaq Pitkow
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
3Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA
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Andreas S. Tolias
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
2Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA
3Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA
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  • For correspondence: astolias@bcm.edu eywalker@bcm.edu fabian.sinz@bcm.edu
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Abstract

Much of our knowledge about sensory processing in the brain is based on quasi-linear models and the stimuli that optimally drive them. However, sensory information processing is nonlinear, even in primary sensory areas, and optimizing sensory input is difficult due to the high-dimensional input space. We developed inception loops, a closed-loop experimental paradigm that combines in vivo recordings with in silico nonlinear response modeling to identify the Most Exciting Images (MEIs) for neurons in mouse V1. When presented back to the brain, MEIs indeed drove their target cells significantly better than the best stimuli identified by linear models. The MEIs exhibited complex spatial features that deviated from the textbook ideal of V1 as a bank of Gabor filters. Inception loops represent a widely applicable new approach to dissect the neural mechanisms of sensation.

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Posted December 28, 2018.
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Inception in visual cortex: in vivo-silico loops reveal most exciting images
Edgar Y. Walke, Fabian H. Sinz, Emmanouil Froudarakis, Paul G. Fahey, Taliah Muhammad, Alexander S. Ecker, Erick Cobos, Jacob Reimer, Xaq Pitkow, Andreas S. Tolias
bioRxiv 506956; doi: https://doi.org/10.1101/506956
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Inception in visual cortex: in vivo-silico loops reveal most exciting images
Edgar Y. Walke, Fabian H. Sinz, Emmanouil Froudarakis, Paul G. Fahey, Taliah Muhammad, Alexander S. Ecker, Erick Cobos, Jacob Reimer, Xaq Pitkow, Andreas S. Tolias
bioRxiv 506956; doi: https://doi.org/10.1101/506956

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