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A generalist pathogen view of diverse host evolutionary histories through polygenic virulence

View ORCID ProfileCeline Caseys, Gongjun Shi, View ORCID ProfileNicole Soltis, Raoni Gwinner, View ORCID ProfileJason Corwin, Susanna Atwell, View ORCID ProfileDaniel Kliebenstein
doi: https://doi.org/10.1101/507491
Celine Caseys
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
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Gongjun Shi
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
2Department of Plant Pathology, North Dakota State University, Fargo, ND, 58102, USA
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Nicole Soltis
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
3Plant Biology Graduate Group, University of California, Davis, One Shields Avenue, Davis, CA 95616 USA
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Raoni Gwinner
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
4Department of Agriculture, Universidade Federal de Lavras, Lavras - MG, 37200- 000, Brazil
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Jason Corwin
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
5Department of Ecology and Evolution Biology, University of Colorado, 1900 Pleasesant Street, 334 UCB, Boulder, CO, 80309-0334, USA
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Susanna Atwell
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
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Daniel Kliebenstein
1Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
6DynaMo Center of Excellence, University of Copenhagen, Thorvaldsensvej 40, DK- 1871, Frederiksberg C, Denmark
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  • For correspondence: Kliebenstein@ucdavis.edu
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Abstract

Host-pathogen interactions display a continuum of host ranges from extreme specialists limited to single hosts to broad generalists with hundreds of hosts. However, the existing models for host-pathogen dynamics are dominated by observations derived from specialist pathogens with qualitative virulence and tight host-pathogen co-evolution. It is not clear how appropriate the co-evolutionary model is in generalist pathogens that present quantitative virulence and broad host specificity. We infected 98 strains of the generalist necrotroph fungus Botrytis cinerea on 90 genotypes representing eight plant species with wild and domestic lines. We show that plant-Botrytis interactions don’t fit traditional co-evolution models as Botrytis interacts with the Eudicot species individually, with little link to the relatedness between plant species or plant domestication. Furthermore, Botrytis host specificity and virulence have distinct polygenic architectures suggesting that the evolution of the Eudicot/Botrytis interactions relies on genome-wide allelic diversity rather than few major virulence loci.

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  • The discussion was expanded

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 25, 2019.
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A generalist pathogen view of diverse host evolutionary histories through polygenic virulence
Celine Caseys, Gongjun Shi, Nicole Soltis, Raoni Gwinner, Jason Corwin, Susanna Atwell, Daniel Kliebenstein
bioRxiv 507491; doi: https://doi.org/10.1101/507491
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A generalist pathogen view of diverse host evolutionary histories through polygenic virulence
Celine Caseys, Gongjun Shi, Nicole Soltis, Raoni Gwinner, Jason Corwin, Susanna Atwell, Daniel Kliebenstein
bioRxiv 507491; doi: https://doi.org/10.1101/507491

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