Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

The virome in adult monozygotic twins with concordant or discordant gut microbiomes

J. Leonardo Moreno-Gallego, Shao-Pei Chou, Sara C. Di Rienzi, Julia K. Goodrich, Timothy Spector, Jordana T. Bell, Youngblut, Ian Hewson, Alejandro Reyes, Ruth E. Ley
doi: https://doi.org/10.1101/509273
J. Leonardo Moreno-Gallego
1Department of Microbiome Science, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shao-Pei Chou
2Department of Molecular Biology and Genetics, Cornell University, Ithaca NY 14853, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sara C. Di Rienzi
2Department of Molecular Biology and Genetics, Cornell University, Ithaca NY 14853, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia K. Goodrich
1Department of Microbiome Science, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timothy Spector
3Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jordana T. Bell
3Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Youngblut
1Department of Microbiome Science, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian Hewson
6Department of Microbiology, Cornell University, Ithaca NY 14853 USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alejandro Reyes
4Max Planck Tandem Group in Computational Biology, Department of Biological Sciences, Universidad de los Andes, Bogotá 111711, Colombia
5Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, MO 63108, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruth E. Ley
1Department of Microbiome Science, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: rley@tuebingen.mpg.de
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

SUMMARY

The virome is one of the most variable components of the human gut microbiome. Within twin-pairs, viromes have been shown to be similar for infants but not for adults, indicating that as twins age and their environments and microbiomes diverge, so do their viromes. The degree to which the microbiome drives the virome’s vast diversity is unclear. Here, we examined the relationship between microbiome diversity and virome diversity in 21 adult monozygotic twin pairs selected for high or low microbiome concordance. Viromes derived from virus-like particles were unique to each subject, dominated by Caudovirales and Microviridae, and exhibited a small core that included crAssphage. Microbiome-discordant twins had more dissimilar viromes compared to microbiome-concordant twins, and the richer the microbiomes, the richer the viromes. These patterns were driven by the bacteriophages, not eukaryotic viruses. These observations support a strong role of the microbiome in patterning the virome.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted January 02, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
The virome in adult monozygotic twins with concordant or discordant gut microbiomes
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
The virome in adult monozygotic twins with concordant or discordant gut microbiomes
J. Leonardo Moreno-Gallego, Shao-Pei Chou, Sara C. Di Rienzi, Julia K. Goodrich, Timothy Spector, Jordana T. Bell, Youngblut, Ian Hewson, Alejandro Reyes, Ruth E. Ley
bioRxiv 509273; doi: https://doi.org/10.1101/509273
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
The virome in adult monozygotic twins with concordant or discordant gut microbiomes
J. Leonardo Moreno-Gallego, Shao-Pei Chou, Sara C. Di Rienzi, Julia K. Goodrich, Timothy Spector, Jordana T. Bell, Youngblut, Ian Hewson, Alejandro Reyes, Ruth E. Ley
bioRxiv 509273; doi: https://doi.org/10.1101/509273

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4370)
  • Biochemistry (9551)
  • Bioengineering (7071)
  • Bioinformatics (24782)
  • Biophysics (12572)
  • Cancer Biology (9925)
  • Cell Biology (14304)
  • Clinical Trials (138)
  • Developmental Biology (7934)
  • Ecology (12082)
  • Epidemiology (2067)
  • Evolutionary Biology (15960)
  • Genetics (10905)
  • Genomics (14709)
  • Immunology (9848)
  • Microbiology (23588)
  • Molecular Biology (9458)
  • Neuroscience (50718)
  • Paleontology (369)
  • Pathology (1535)
  • Pharmacology and Toxicology (2675)
  • Physiology (4001)
  • Plant Biology (8645)
  • Scientific Communication and Education (1505)
  • Synthetic Biology (2388)
  • Systems Biology (6415)
  • Zoology (1345)