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Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
Benjamin A. Logsdon, Thanneer M. Perumal, Vivek Swarup, Minghui Wang, Cory Funk, Chris Gaiteri, Mariet Allen, Xue Wang, Eric Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C. Airey, Gregory W. Carter, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, the AMP-AD Consortium, David A. Collier, Todd Golde, Allan Levey, David A. Bennett, Karol Estrada, Michael Decker, Zhandong Liu, Joshua M. Shulman, Bin Zhang, Eric Schadt, Phillip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Lara M. Mangravite
doi: https://doi.org/10.1101/510420
Benjamin A. Logsdon
1Sage Bionetworks, Seattle, WA, 98121, USA
2Lead contact
Thanneer M. Perumal
1Sage Bionetworks, Seattle, WA, 98121, USA
Vivek Swarup
3Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Minghui Wang
4Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Cory Funk
5Institute for Systems Biology, Seattle, WA, USA
Chris Gaiteri
6Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Mariet Allen
7Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
Xue Wang
7Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
8Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, 32224, USA
Eric Dammer
9Emory University, Atlanta, GA, USA
Gyan Srivastava
10AbbVie, Boston, MA, USA
Sumit Mukherjee
1Sage Bionetworks, Seattle, WA, 98121, USA
Solveig K. Sieberts
1Sage Bionetworks, Seattle, WA, 98121, USA
Larsson Omberg
1Sage Bionetworks, Seattle, WA, 98121, USA
Kristen D. Dang
1Sage Bionetworks, Seattle, WA, 98121, USA
James A. Eddy
1Sage Bionetworks, Seattle, WA, 98121, USA
Phil Snyder
1Sage Bionetworks, Seattle, WA, 98121, USA
Yooree Chae
11Genentech, South San Francisco, CA, 94080, USA
Sandeep Amberkar
12Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Wenbin Wei
12Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Winston Hide
12Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Christoph Preuss
13The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA 04609
Ayla Ergun
14Biogen, Cambridge, MA, USA
Phillip J Ebert
15Eli Lilly, Indianapolis, IN, USA
David C. Airey
15Eli Lilly, Indianapolis, IN, USA
Gregory W. Carter
14Biogen, Cambridge, MA, USA
Sara Mostafavi
16University of British Columbia, Vancouver, BC, Canada
Lei Yu
6Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Hans-Ulrich Klein
17Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA
18Full list of consortia authors and affiliations (doi:10.7303/syn17114455)
David A. Collier
15Eli Lilly, Indianapolis, IN, USA
Todd Golde
19University of Florida, Gainesville, FL, USA
Allan Levey
9Emory University, Atlanta, GA, USA
David A. Bennett
6Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Karol Estrada
20Translational Genome Sciences, Biogen, Cambridge, MA 02142 USA
Michael Decker
10AbbVie, Boston, MA, USA
Zhandong Liu
21Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
22Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA
Joshua M. Shulman
22Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA
23Departments of Neurology, Neuroscience, and Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA
Bin Zhang
4Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Eric Schadt
4Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Phillip L. De Jager
17Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA
Nathan D. Price
5Institute for Systems Biology, Seattle, WA, USA
Nilüfer Ertekin-Taner
7Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
24Department of Neurology, Mayo Clinic, Jacksonville, FL, 32224, USA
Lara M. Mangravite
1Sage Bionetworks, Seattle, WA, 98121, USA
Posted January 03, 2019.
Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
Benjamin A. Logsdon, Thanneer M. Perumal, Vivek Swarup, Minghui Wang, Cory Funk, Chris Gaiteri, Mariet Allen, Xue Wang, Eric Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C. Airey, Gregory W. Carter, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, the AMP-AD Consortium, David A. Collier, Todd Golde, Allan Levey, David A. Bennett, Karol Estrada, Michael Decker, Zhandong Liu, Joshua M. Shulman, Bin Zhang, Eric Schadt, Phillip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Lara M. Mangravite
bioRxiv 510420; doi: https://doi.org/10.1101/510420
Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
Benjamin A. Logsdon, Thanneer M. Perumal, Vivek Swarup, Minghui Wang, Cory Funk, Chris Gaiteri, Mariet Allen, Xue Wang, Eric Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C. Airey, Gregory W. Carter, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, the AMP-AD Consortium, David A. Collier, Todd Golde, Allan Levey, David A. Bennett, Karol Estrada, Michael Decker, Zhandong Liu, Joshua M. Shulman, Bin Zhang, Eric Schadt, Phillip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Lara M. Mangravite
bioRxiv 510420; doi: https://doi.org/10.1101/510420
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