Whole Genome Doubling mitigates Muller’s Ratchet in Cancer Evolution

Saioa López; Emilia Lim; Ariana Huebner; Michelle Dietzen; Thanos Mourikis; Thomas B.K. Watkins; Andrew Rowan; Sally M. Dewhurst; Nicolai J. Birkbak; Gareth A. Wilson; Mariam Jamal-Hanjani; Charles Swanton; on behalf of TRACERx Consortium; Nicholas McGranahan

doi:10.1101/513457

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Whole Genome Doubling mitigates Muller’s Ratchet in Cancer Evolution

Saioa López, Emilia Lim, Ariana Huebner, Michelle Dietzen, Thanos Mourikis, Thomas B.K. Watkins, Andrew Rowan, Sally M. Dewhurst, Nicolai J. Birkbak, Gareth A. Wilson, Mariam Jamal-Hanjani, Charles Swanton, on behalf of TRACERx Consortium, Nicholas McGranahan

doi: https://doi.org/10.1101/513457

Saioa López

1Cancer Genome Evolution Research Group, University College London Cancer Institute. London, UK

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

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Emilia Lim

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Ariana Huebner

1Cancer Genome Evolution Research Group, University College London Cancer Institute. London, UK

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Michelle Dietzen

1Cancer Genome Evolution Research Group, University College London Cancer Institute. London, UK

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Thanos Mourikis

1Cancer Genome Evolution Research Group, University College London Cancer Institute. London, UK

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

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Thomas B.K. Watkins

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Andrew Rowan

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Sally M. Dewhurst

4Laboratory for Cell Biology and Genetics. The Rockefeller University. New York, US

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Nicolai J. Birkbak

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

5Department of Molecular Medicine, Aarhus University, Aarhus, Denmark

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Gareth A. Wilson

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Mariam Jamal-Hanjani

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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Charles Swanton

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

3Cancer Evolution and Genome Instability Laboratory, the Francis Crick Institute and University College London Cancer Institute. London, UK

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For correspondence: charles.swanton@crick.ac.uk nicholas.mcgranahan.10@ucl.ac.uk

Nicholas McGranahan

1Cancer Genome Evolution Research Group, University College London Cancer Institute. London, UK

2Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute. London, UK

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For correspondence: charles.swanton@crick.ac.uk nicholas.mcgranahan.10@ucl.ac.uk