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Comprehensive Substrate Specificity Profiling of the Human Nek Kinome Reveals Unexpected Signaling Outputs
Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, View ORCID ProfileBrian A. Joughin, Chad J. Miller, Nasir Haider, Rune Linding, View ORCID ProfileVuk Stambolic, Benjamin E. Turk, View ORCID ProfileMichael B. Yaffe
doi: https://doi.org/10.1101/515221
Bert van de Kooij
1Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Pau Creixell
1Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Anne van Vlimmeren
1Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Brian A. Joughin
1Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Chad J. Miller
2Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA
Nasir Haider
3Department of Medical Biophysics, University of Toronto, Toronto, Canada
Rune Linding
4Biotech Research and Innovation Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Vuk Stambolic
3Department of Medical Biophysics, University of Toronto, Toronto, Canada
Benjamin E. Turk
2Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA
Michael B. Yaffe
1Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA
5Department of Surgery, Beth Israel Deaconess Medical Center, Divisions of Acute Care Surgery, Trauma, and Critical Care and Surgical Oncology, Harvard Medical School, Boston, USA
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Posted January 08, 2019.
Comprehensive Substrate Specificity Profiling of the Human Nek Kinome Reveals Unexpected Signaling Outputs
Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A. Joughin, Chad J. Miller, Nasir Haider, Rune Linding, Vuk Stambolic, Benjamin E. Turk, Michael B. Yaffe
bioRxiv 515221; doi: https://doi.org/10.1101/515221
Comprehensive Substrate Specificity Profiling of the Human Nek Kinome Reveals Unexpected Signaling Outputs
Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A. Joughin, Chad J. Miller, Nasir Haider, Rune Linding, Vuk Stambolic, Benjamin E. Turk, Michael B. Yaffe
bioRxiv 515221; doi: https://doi.org/10.1101/515221
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