Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

Yury S. Bykov; Nir Cohen; Natalia Gabrielli; Hetty Manenschijn; Sonja Welsch; Petr Chlanda; Wanda Kukulski; Kiran R. Patil; Maya Schuldiner; John A.G. Briggs

doi:10.1101/515841

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Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

View ORCID ProfileYury S. Bykov, View ORCID ProfileNir Cohen, View ORCID ProfileNatalia Gabrielli, View ORCID ProfileHetty Manenschijn, View ORCID ProfileSonja Welsch, View ORCID ProfilePetr Chlanda, View ORCID ProfileWanda Kukulski, View ORCID ProfileKiran R. Patil, View ORCID ProfileMaya Schuldiner, John A.G. Briggs

doi: https://doi.org/10.1101/515841

Yury S. Bykov

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

2Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CB2 0QH, Cambridge, UK

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Nir Cohen

3Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel

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Natalia Gabrielli

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Hetty Manenschijn

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

4Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Sonja Welsch

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Petr Chlanda

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Wanda Kukulski

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

4Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Kiran R. Patil

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Maya Schuldiner

3Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel

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For correspondence: john.briggs@mrc-lmb.cam.ac.uk maya.shuldiner@weizmann.ac.il

John A.G. Briggs

1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

2Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CB2 0QH, Cambridge, UK

4Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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For correspondence: john.briggs@mrc-lmb.cam.ac.uk maya.shuldiner@weizmann.ac.il

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Posted January 09, 2019.

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Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

Yury S. Bykov, Nir Cohen, Natalia Gabrielli, Hetty Manenschijn, Sonja Welsch, Petr Chlanda, Wanda Kukulski, Kiran R. Patil, Maya Schuldiner, John A.G. Briggs

bioRxiv 515841; doi: https://doi.org/10.1101/515841

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Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

Yury S. Bykov, Nir Cohen, Natalia Gabrielli, Hetty Manenschijn, Sonja Welsch, Petr Chlanda, Wanda Kukulski, Kiran R. Patil, Maya Schuldiner, John A.G. Briggs

bioRxiv 515841; doi: https://doi.org/10.1101/515841

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