Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Expanding the watch list for potential Ebola virus antibody escape mutations

View ORCID ProfileJagdish Suresh Patel, Caleb J. Quates, Erin L. Johnson, F. Marty Ytreberg
doi: https://doi.org/10.1101/516161
Jagdish Suresh Patel
University of Idaho
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jagdish Suresh Patel
  • For correspondence: thejagdishpatel@gmail.com
Caleb J. Quates
University of Idaho
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: calebquates@gmail.com
Erin L. Johnson
University of Idaho
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: johnsonel1994@gmail.com
F. Marty Ytreberg
University of Idaho
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ytreberg@uidaho.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The 2014 outbreak of Ebola virus (EBOV) in Western Africa is the largest recorded filovirus disease outbreak and lead to the death of over 11,000 people. This deadly virus still poses a grave epidemic threat as evidenced by the current (since May 2018) EBOV outbreak in the Democratic Republic of the Congo which has already claimed the lives of over 250 people. One important strategy for combating EBOV epidemics is to anticipate how the evolution of EBOV might undermine treatment since the development of vaccines and antibody therapies are typically based on a single strain (often the 1976 Mayinga) of the EBOV envelope glycoprotein (GP). In a previous study we initiated a watch list of potential antibody escape mutations of EBOV by modeling interactions between EBOV GP and the monoclonal antibody KZ52. This watch list was generated using molecular modeling to estimate the effect of every possible mutation of GP. The final watch list containing 34 mutations were predicted to disrupt GP-KZ52 binding but not to disrupt the ability of GP to fold and to form trimers. In this study, we expand our watch list by including three more monoclonal antibodies with distinct epitopes on GP, namely Antibody 100 (Ab100), Antibody 114 (Ab114) and 13F6-1-2. Our updated watch list contains 127 mutations, three of which have been seen in humans or are experimentally associated with reduced efficacy of antibody treatment. We believe mutations on this broad watch list require attention since they may be a signal of an evolutionary response from EBOV to treatment that could diminish the effectiveness of interventions.

Footnotes

  • Supplemental Files are added

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted January 09, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Expanding the watch list for potential Ebola virus antibody escape mutations
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Expanding the watch list for potential Ebola virus antibody escape mutations
Jagdish Suresh Patel, Caleb J. Quates, Erin L. Johnson, F. Marty Ytreberg
bioRxiv 516161; doi: https://doi.org/10.1101/516161
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Expanding the watch list for potential Ebola virus antibody escape mutations
Jagdish Suresh Patel, Caleb J. Quates, Erin L. Johnson, F. Marty Ytreberg
bioRxiv 516161; doi: https://doi.org/10.1101/516161

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biophysics
Subject Areas
All Articles
  • Animal Behavior and Cognition (1537)
  • Biochemistry (2494)
  • Bioengineering (1751)
  • Bioinformatics (9712)
  • Biophysics (3923)
  • Cancer Biology (2983)
  • Cell Biology (4225)
  • Clinical Trials (135)
  • Developmental Biology (2645)
  • Ecology (4116)
  • Epidemiology (2033)
  • Evolutionary Biology (6919)
  • Genetics (5229)
  • Genomics (6528)
  • Immunology (2201)
  • Microbiology (6988)
  • Molecular Biology (2774)
  • Neuroscience (17378)
  • Paleontology (126)
  • Pathology (432)
  • Pharmacology and Toxicology (709)
  • Physiology (1064)
  • Plant Biology (2508)
  • Scientific Communication and Education (646)
  • Synthetic Biology (835)
  • Systems Biology (2695)
  • Zoology (437)