New Results
Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes
Pamela Feliciano, Xueya Zhou, Irina Astrovskaya, Tychele N. Turner, Tianyun Wang, Leo Brueggeman, Rebecca Barnard, Alexander Hsieh, LeeAnne Green Snyder, Donna M. Muzny, Aniko Sabo, The SPARK Consortium, Richard A. Gibbs, Evan E. Eichler, Brian J. O’Roak, Jacob J. Michaelson, Natalia Volfovsky, Yufeng Shen, Wendy K. Chung, Leonard Abbeduto, John Acampado, Andrea J. Ace, Charles Albright, Michael Alessandri, David G. Amaral, Alpha Amatya, Robert D. Annett, Ivette Arriaga, Irina Astrovskaya, Ethan Bahl, Adithya Balasubramanian, Nicole Bardett, Rebecca A. Barnard, Asif Bashar, Arthur Beaudet, Landon Beeson, Raphael A. Bernier, Elizabeth Berry-Kravis, Stephanie Booker, Stephanie J. Brewster, Elizabeth Brooks, Leo Brueggeman, Martin E. Butler, Eric M. Butter, Kristen Callahan, Alexies Camba, Sarah Carpenter, Nicholas Carriero, Lindsey A. Cartner, Ahmad S. Chatha, Wubin Chin, Wendy K. Chung, Renee D. Clark, Cheryl Cohen, Eric Courchesne, Joseph F. Cubells, Mary Hannah Currin, Amy M. Daniels, Lindsey DeMarco, Megan Y. Dennis, Gabriel S. Dichter, Yan Ding, Huyen Dinh, Ryan Doan, HarshaVardhan Doddapaneni, Evan E. Eichler, Sara Eldred, Christine Eng, Craig A. Erickson, Amy Esler, Ali Fatemi, Pamela Feliciano, Gregory Fischer, Ian Fisk, Eric J. Fombonne, Emily A. Fox, Sunday Francis, Sandra L. Friedman, Swami Ganesan, Michael Garrett, Vahid Gazestani, Madeleine R. Geisheker, Jennifer A. Gerdts, Daniel H. Geschwind, Richard A. Gibbs, Robin P. Goin-Kochel, Anthony J.Griswold, Luke P. Grosvenor, Angela J. Gruber, Amanda C. Gulsrud, Jaclyn Gunderson, Anibal Gutierrez, Melissa N. Hale, Monica Haley, Jacob B. Hall, Kira E. Hamer, Bing Han, Nathan Hanna, Christina Harkins, Nina Harris, Brenda Hauf, Caitlin Hayes, Susan L. Hepburn, Lynette M. Herbert, Michelle Heyman, Brittani A. Hilscher, Susannah Horner, Alexander Hsieh, Jianhong Hu, Lark Y. Huang-Storms, Hanna Hutter, Dalia Istephanous, Suma Jacob, William Jensen, Mark Jones, Michelle Jordy, A. Pablo Juarez, Stephen Kanne, Hannah E. Kaplan, Matt Kent, Alex Kitaygorodsky, Tanner Koomar, Viktoriya Korchina, Anthony D. Krentz, Hoa Lam Schneider, Elena Lamarche, Rebecca J. Landa, Alex E. Lash, J. Kiely Law, Noah Lawson, Kevin Layman, Holly Lechniak, Sandra Lee, Soo J. Lee, Daniel Lee Coury, Christa Lese Martin, Hai Li, Deana Li, Natasha Lillie, Xiuping Liu, Catherine Lord, Malcolm D. Mallardi, Patricia Manning, Julie Manoharan, Richard Marini, Gabriela Marzano, Andrew Mason, Emily T. Matthews, James T. McCracken, Alexander P. McKenzie, Jacob J. Michaelson, Zeineen Momin, Michael J. Morrier, Shwetha Murali, Donna Muzny, Vincent J. Myers, Jason Neely, Caitlin Nessner, Amy Nicholson, Kaela O’Brien, Eirene O’Connor, Brian J. O’Roak, Cesar Ochoa-Lubinoff, Jessica Orobio, Opal Y. Ousley, Lillian D. Pacheco, Juhi Pandey, Anna Marie Paolicelli, Katherine G. Pawlowski, Karen L. Pierce, Joseph Piven, Samantha Plate, Marc Popp, Tiziano Pramparo, Lisa M. Prock, Hongjian Qi, Shanping Qiu, Angela L. Rachubinski, Kshitij Rajbhandari, Rishiraj Rana, Rick Remington, Catherine E. Rice, Chris Rigby, Beverly E. Robertson, Katherine Roeder, Cordelia R. Rosenberg, Nicole Russo-Ponsaran, Elizabeth Ruzzo, Aniko Sabo, Mustafa Sahin, Andrei Salomatov, Sophia Sandhu, Susan Santangelo, Dustin E. Sarver, Jessica Scherr, Robert T. Schultz, Kathryn A. Schweers, Swapnil Shah, Tamim Shaikh, Yufeng Shen, Amanda D. Shocklee, Andrea R. Simon, Laura Simon, Vini Singh, Steve Skinner, Christopher J. Smith, Kaitlin Smith, LeeAnne G. Snyder, Latha V. Soorya, Aubrie Soucy, Alexandra N. Stephens, Colleen M. Stock, James S. Sutcliffe, James S. Sutcliffe, Amy Swanson, Maira Tafolla, Nicole Takahashi, Carrie Thomas, Taylor Thomas, Samantha Thompson, Jennifer Tjernagel, Tychele N. Turner, Bonnie Van Metre, Jeremy Veenstra-Vanderweele, Brianna M. Vernoia, Natalia Volfovsky, Jermel Wallace, Corrie H. Walston, Jiayao Wang, Tianyun Wang, Zachary Warren, Lucy Wasserburg, Loran Casey White, Sabrina White, Ericka L. Wodka, Simon Xu, Wha S. Yang, Meredith Yinger, Timothy Yu, Lan Zang, Hana Zaydens, Haicang Zhang, Haoquan Zhao, Xueya Zhou
doi: https://doi.org/10.1101/516625
Pamela Feliciano
1Simons Foundation, New York, New York 10010
Xueya Zhou
2Department of Systems Biology, Columbia University, New York, New York 10032
Irina Astrovskaya
1Simons Foundation, New York, New York 10010
Tychele N. Turner
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
Tianyun Wang
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
Leo Brueggeman
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Rebecca Barnard
5Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239
Alexander Hsieh
2Department of Systems Biology, Columbia University, New York, New York 10032
LeeAnne Green Snyder
1Simons Foundation, New York, New York 10010
Donna M. Muzny
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Aniko Sabo
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Richard A. Gibbs
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Evan E. Eichler
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
7University of Washington, Howard Hughes Medical Institute, Seattle, Washington 98195
Brian J. O’Roak
5Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239
Jacob J. Michaelson
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Natalia Volfovsky
1Simons Foundation, New York, New York 10010
Yufeng Shen
2Department of Systems Biology, Columbia University, New York, New York 10032
Wendy K. Chung
1Simons Foundation, New York, New York 10010
8Department of Pediatrics, Columbia University Medical Center, New York, New York 10032
Leonard Abbeduto
9MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817
John Acampado
1Simons Foundation, New York, New York 10010
Andrea J. Ace
1Simons Foundation, New York, New York 10010
Charles Albright
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Michael Alessandri
11Department of Psychology, University of Miami, Coral Gables, Florida 33146
David G. Amaral
9MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817
Alpha Amatya
1Simons Foundation, New York, New York 10010
Robert D. Annett
12Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216
Ivette Arriaga
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Irina Astrovskaya
1Simons Foundation, New York, New York 10010
Ethan Bahl
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Adithya Balasubramanian
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Nicole Bardett
15Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Rebecca A. Barnard
5Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239
Asif Bashar
1Simons Foundation, New York, New York 10010
Arthur Beaudet
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Landon Beeson
16Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612
Raphael A. Bernier
17Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195
Elizabeth Berry-Kravis
18Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612
19Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612
20Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612
Stephanie Booker
21Department of Psychiatry and Behavioral Neuroscience, Cincinnati Children’s Hospital Medical Center - Research Foundation, Cincinnati, Ohio 45229
Stephanie J. Brewster
22Translational Neuroscience Center, Boston Children’s Hospital, Boston, Massachusetts 02115
Elizabeth Brooks
1Simons Foundation, New York, New York 10010
Leo Brueggeman
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Martin E. Butler
1Simons Foundation, New York, New York 10010
Eric M. Butter
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Kristen Callahan
12Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216
Alexies Camba
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Sarah Carpenter
15Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Nicholas Carriero
1Simons Foundation, New York, New York 10010
Lindsey A. Cartner
1Simons Foundation, New York, New York 10010
Ahmad S. Chatha
1Simons Foundation, New York, New York 10010
Wubin Chin
1Simons Foundation, New York, New York 10010
Wendy K. Chung
1Simons Foundation, New York, New York 10010
8Department of Pediatrics, Columbia University Medical Center, New York, New York 10032
Renee D. Clark
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Cheryl Cohen
24Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21211
Eric Courchesne
25Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92037
Joseph F. Cubells
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Mary Hannah Currin
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Amy M. Daniels
1Simons Foundation, New York, New York 10010
Lindsey DeMarco
27Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19146
Megan Y. Dennis
28Genome Center, MIND Institute, Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, California 95616
Gabriel S. Dichter
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Yan Ding
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Huyen Dinh
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Ryan Doan
29Department of Medicine, Boston Childrens Hospital, Boston, Massachusetts 02115
HarshaVardhan Doddapaneni
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Evan E. Eichler
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
7University of Washington, Howard Hughes Medical Institute, Seattle, Washington 98195
Sara Eldred
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Christine Eng
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Craig A. Erickson
21Department of Psychiatry and Behavioral Neuroscience, Cincinnati Children’s Hospital Medical Center - Research Foundation, Cincinnati, Ohio 45229
Amy Esler
30Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55414
Ali Fatemi
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Pamela Feliciano
1Simons Foundation, New York, New York 10010
Gregory Fischer
32PreventionGenetics, Marshfield, Wisconsin 54449
Ian Fisk
1Simons Foundation, New York, New York 10010
Eric J. Fombonne
33Department of Psychiatry, Oregon Health & Science University, Portland, Oregon 97239
Emily A. Fox
17Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195
Sunday Francis
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Sandra L. Friedman
35Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045
Swami Ganesan
1Simons Foundation, New York, New York 10010
Michael Garrett
36Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216
Vahid Gazestani
37Department of Pediatrics, University of California, San Diego, La Jolla, California 92161
Madeleine R. Geisheker
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
Jennifer A. Gerdts
17Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195
Daniel H. Geschwind
38Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095
Richard A. Gibbs
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Robin P. Goin-Kochel
39Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
Anthony J.Griswold
40John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida 33136
Luke P. Grosvenor
1Simons Foundation, New York, New York 10010
Angela J. Gruber
32PreventionGenetics, Marshfield, Wisconsin 54449
Amanda C. Gulsrud
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Jaclyn Gunderson
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Anibal Gutierrez
11Department of Psychology, University of Miami, Coral Gables, Florida 33146
Melissa N. Hale
11Department of Psychology, University of Miami, Coral Gables, Florida 33146
Monica Haley
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Jacob B. Hall
1Simons Foundation, New York, New York 10010
Kira E. Hamer
17Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195
Bing Han
1Simons Foundation, New York, New York 10010
Nathan Hanna
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Christina Harkins
21Department of Psychiatry and Behavioral Neuroscience, Cincinnati Children’s Hospital Medical Center - Research Foundation, Cincinnati, Ohio 45229
Nina Harris
15Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Brenda Hauf
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Caitlin Hayes
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Susan L. Hepburn
41Human Development & Family Studies, Colorado State University, Fort Collins, Colorado 80524
Lynette M. Herbert
11Department of Psychology, University of Miami, Coral Gables, Florida 33146
Michelle Heyman
42Department of Psychiatry, Weill Cornell Medicine, White Plains, New York 10605
Brittani A. Hilscher
9MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817
Susannah Horner
27Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19146
Alexander Hsieh
2Department of Systems Biology, Columbia University, New York, New York 10032
Jianhong Hu
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Lark Y. Huang-Storms
33Department of Psychiatry, Oregon Health & Science University, Portland, Oregon 97239
Hanna Hutter
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Dalia Istephanous
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Suma Jacob
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
William Jensen
1Simons Foundation, New York, New York 10010
Mark Jones
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Michelle Jordy
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
A. Pablo Juarez
43Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Stephen Kanne
44Department of Health Psychology, University of Missouri, Columbia, Missouri 65211
45Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, Missouri 65211
Hannah E. Kaplan
25Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92037
Matt Kent
1Simons Foundation, New York, New York 10010
Alex Kitaygorodsky
2Department of Systems Biology, Columbia University, New York, New York 10032
Tanner Koomar
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Viktoriya Korchina
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Anthony D. Krentz
32PreventionGenetics, Marshfield, Wisconsin 54449
Hoa Lam Schneider
11Department of Psychology, University of Miami, Coral Gables, Florida 33146
Elena Lamarche
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Rebecca J. Landa
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Alex E. Lash
1Simons Foundation, New York, New York 10010
J. Kiely Law
24Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21211
Noah Lawson
1Simons Foundation, New York, New York 10010
Kevin Layman
1Simons Foundation, New York, New York 10010
Holly Lechniak
16Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612
Sandra Lee
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Soo J. Lee
16Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612
Daniel Lee Coury
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Christa Lese Martin
46Autism & Developmental Medicine Institute, Geisinger Autism & Developmental Medicine Institute, Lewisburg, Pennsylvania 17837
Hai Li
19Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612
Deana Li
9MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817
Natasha Lillie
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Xiuping Liu
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Catherine Lord
42Department of Psychiatry, Weill Cornell Medicine, White Plains, New York 10605
Malcolm D. Mallardi
1Simons Foundation, New York, New York 10010
Patricia Manning
21Department of Psychiatry and Behavioral Neuroscience, Cincinnati Children’s Hospital Medical Center - Research Foundation, Cincinnati, Ohio 45229
Julie Manoharan
1Simons Foundation, New York, New York 10010
Richard Marini
1Simons Foundation, New York, New York 10010
Gabriela Marzano
39Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
Andrew Mason
47Research, Southwest Autism Research and Resource Center, Phoenix, Arizona 85006
Emily T. Matthews
48Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts 02115
James T. McCracken
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Alexander P. McKenzie
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Jacob J. Michaelson
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Zeineen Momin
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Michael J. Morrier
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Shwetha Murali
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
Donna Muzny
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Vincent J. Myers
1Simons Foundation, New York, New York 10010
Jason Neely
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Caitlin Nessner
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Amy Nicholson
43Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Kaela O’Brien
21Department of Psychiatry and Behavioral Neuroscience, Cincinnati Children’s Hospital Medical Center - Research Foundation, Cincinnati, Ohio 45229
Eirene O’Connor
1Simons Foundation, New York, New York 10010
Brian J. O’Roak
5Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239
Cesar Ochoa-Lubinoff
19Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612
Jessica Orobio
39Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
Opal Y. Ousley
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Lillian D. Pacheco
33Department of Psychiatry, Oregon Health & Science University, Portland, Oregon 97239
Juhi Pandey
27Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19146
Anna Marie Paolicelli
42Department of Psychiatry, Weill Cornell Medicine, White Plains, New York 10605
Katherine G. Pawlowski
48Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts 02115
Karen L. Pierce
25Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92037
Joseph Piven
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Samantha Plate
27Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19146
Marc Popp
32PreventionGenetics, Marshfield, Wisconsin 54449
Tiziano Pramparo
25Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92037
Lisa M. Prock
48Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts 02115
Hongjian Qi
2Department of Systems Biology, Columbia University, New York, New York 10032
Shanping Qiu
42Department of Psychiatry, Weill Cornell Medicine, White Plains, New York 10605
Angela L. Rachubinski
35Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045
Kshitij Rajbhandari
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Rishiraj Rana
1Simons Foundation, New York, New York 10010
Rick Remington
1Simons Foundation, New York, New York 10010
Catherine E. Rice
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Chris Rigby
1Simons Foundation, New York, New York 10010
Beverly E. Robertson
1Simons Foundation, New York, New York 10010
Katherine Roeder
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Cordelia R. Rosenberg
35Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045
Nicole Russo-Ponsaran
49Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60612
Elizabeth Ruzzo
38Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095
Aniko Sabo
6Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Mustafa Sahin
50Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115
Andrei Salomatov
1Simons Foundation, New York, New York 10010
Sophia Sandhu
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Susan Santangelo
51Maine Medical Center Research Institute, Portland, Maine 04101
Dustin E. Sarver
12Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216
Jessica Scherr
10Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital, Columbus, Ohio 43205
Robert T. Schultz
27Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19146
Kathryn A. Schweers
16Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612
Swapnil Shah
1Simons Foundation, New York, New York 10010
Tamim Shaikh
35Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045
Yufeng Shen
2Department of Systems Biology, Columbia University, New York, New York 10032
Amanda D. Shocklee
45Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, Missouri 65211
Andrea R. Simon
39Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
Laura Simon
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Vini Singh
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Steve Skinner
52Greenwood Genetic Center, Greenwood, South Carolina 29646
Christopher J. Smith
47Research, Southwest Autism Research and Resource Center, Phoenix, Arizona 85006
Kaitlin Smith
9MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817
LeeAnne G. Snyder
1Simons Foundation, New York, New York 10010
Latha V. Soorya
16Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612
Aubrie Soucy
29Department of Medicine, Boston Childrens Hospital, Boston, Massachusetts 02115
Alexandra N. Stephens
1Simons Foundation, New York, New York 10010
Colleen M. Stock
1Simons Foundation, New York, New York 10010
James S. Sutcliffe
53Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee 37232
James S. Sutcliffe
54Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Amy Swanson
15Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Maira Tafolla
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Nicole Takahashi
45Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, Missouri 65211
Carrie Thomas
21Department of Psychiatry and Behavioral Neuroscience, Cincinnati Children’s Hospital Medical Center - Research Foundation, Cincinnati, Ohio 45229
Taylor Thomas
4Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
Samantha Thompson
9MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817
Jennifer Tjernagel
1Simons Foundation, New York, New York 10010
Tychele N. Turner
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
Bonnie Van Metre
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Jeremy Veenstra-Vanderweele
55Department of Psychiatry, Columbia University Medical Center, New York, New York 10032
Brianna M. Vernoia
1Simons Foundation, New York, New York 10010
Natalia Volfovsky
1Simons Foundation, New York, New York 10010
Jermel Wallace
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Corrie H. Walston
23Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
Jiayao Wang
2Department of Systems Biology, Columbia University, New York, New York 10032
Tianyun Wang
3Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195
Zachary Warren
43Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Lucy Wasserburg
34Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Loran Casey White
1Simons Foundation, New York, New York 10010
Sabrina White
12Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216
Ericka L. Wodka
31Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, Maryland 21211
Simon Xu
1Simons Foundation, New York, New York 10010
Wha S. Yang
13Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
Meredith Yinger
26Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University, Atlanta, Georgia 30033
Timothy Yu
29Department of Medicine, Boston Childrens Hospital, Boston, Massachusetts 02115
Lan Zang
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030
Hana Zaydens
1Simons Foundation, New York, New York 10010
Haicang Zhang
2Department of Systems Biology, Columbia University, New York, New York 10032
Haoquan Zhao
2Department of Systems Biology, Columbia University, New York, New York 10032
Xueya Zhou
2Department of Systems Biology, Columbia University, New York, New York 10032
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Posted January 09, 2019.
Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes
Pamela Feliciano, Xueya Zhou, Irina Astrovskaya, Tychele N. Turner, Tianyun Wang, Leo Brueggeman, Rebecca Barnard, Alexander Hsieh, LeeAnne Green Snyder, Donna M. Muzny, Aniko Sabo, The SPARK Consortium, Richard A. Gibbs, Evan E. Eichler, Brian J. O’Roak, Jacob J. Michaelson, Natalia Volfovsky, Yufeng Shen, Wendy K. Chung, Leonard Abbeduto, John Acampado, Andrea J. Ace, Charles Albright, Michael Alessandri, David G. Amaral, Alpha Amatya, Robert D. Annett, Ivette Arriaga, Irina Astrovskaya, Ethan Bahl, Adithya Balasubramanian, Nicole Bardett, Rebecca A. Barnard, Asif Bashar, Arthur Beaudet, Landon Beeson, Raphael A. Bernier, Elizabeth Berry-Kravis, Stephanie Booker, Stephanie J. Brewster, Elizabeth Brooks, Leo Brueggeman, Martin E. Butler, Eric M. Butter, Kristen Callahan, Alexies Camba, Sarah Carpenter, Nicholas Carriero, Lindsey A. Cartner, Ahmad S. Chatha, Wubin Chin, Wendy K. Chung, Renee D. Clark, Cheryl Cohen, Eric Courchesne, Joseph F. Cubells, Mary Hannah Currin, Amy M. Daniels, Lindsey DeMarco, Megan Y. Dennis, Gabriel S. Dichter, Yan Ding, Huyen Dinh, Ryan Doan, HarshaVardhan Doddapaneni, Evan E. Eichler, Sara Eldred, Christine Eng, Craig A. Erickson, Amy Esler, Ali Fatemi, Pamela Feliciano, Gregory Fischer, Ian Fisk, Eric J. Fombonne, Emily A. Fox, Sunday Francis, Sandra L. Friedman, Swami Ganesan, Michael Garrett, Vahid Gazestani, Madeleine R. Geisheker, Jennifer A. Gerdts, Daniel H. Geschwind, Richard A. Gibbs, Robin P. Goin-Kochel, Anthony J.Griswold, Luke P. Grosvenor, Angela J. Gruber, Amanda C. Gulsrud, Jaclyn Gunderson, Anibal Gutierrez, Melissa N. Hale, Monica Haley, Jacob B. Hall, Kira E. Hamer, Bing Han, Nathan Hanna, Christina Harkins, Nina Harris, Brenda Hauf, Caitlin Hayes, Susan L. Hepburn, Lynette M. Herbert, Michelle Heyman, Brittani A. Hilscher, Susannah Horner, Alexander Hsieh, Jianhong Hu, Lark Y. Huang-Storms, Hanna Hutter, Dalia Istephanous, Suma Jacob, William Jensen, Mark Jones, Michelle Jordy, A. Pablo Juarez, Stephen Kanne, Hannah E. Kaplan, Matt Kent, Alex Kitaygorodsky, Tanner Koomar, Viktoriya Korchina, Anthony D. Krentz, Hoa Lam Schneider, Elena Lamarche, Rebecca J. Landa, Alex E. Lash, J. Kiely Law, Noah Lawson, Kevin Layman, Holly Lechniak, Sandra Lee, Soo J. Lee, Daniel Lee Coury, Christa Lese Martin, Hai Li, Deana Li, Natasha Lillie, Xiuping Liu, Catherine Lord, Malcolm D. Mallardi, Patricia Manning, Julie Manoharan, Richard Marini, Gabriela Marzano, Andrew Mason, Emily T. Matthews, James T. McCracken, Alexander P. McKenzie, Jacob J. Michaelson, Zeineen Momin, Michael J. Morrier, Shwetha Murali, Donna Muzny, Vincent J. Myers, Jason Neely, Caitlin Nessner, Amy Nicholson, Kaela O’Brien, Eirene O’Connor, Brian J. O’Roak, Cesar Ochoa-Lubinoff, Jessica Orobio, Opal Y. Ousley, Lillian D. Pacheco, Juhi Pandey, Anna Marie Paolicelli, Katherine G. Pawlowski, Karen L. Pierce, Joseph Piven, Samantha Plate, Marc Popp, Tiziano Pramparo, Lisa M. Prock, Hongjian Qi, Shanping Qiu, Angela L. Rachubinski, Kshitij Rajbhandari, Rishiraj Rana, Rick Remington, Catherine E. Rice, Chris Rigby, Beverly E. Robertson, Katherine Roeder, Cordelia R. Rosenberg, Nicole Russo-Ponsaran, Elizabeth Ruzzo, Aniko Sabo, Mustafa Sahin, Andrei Salomatov, Sophia Sandhu, Susan Santangelo, Dustin E. Sarver, Jessica Scherr, Robert T. Schultz, Kathryn A. Schweers, Swapnil Shah, Tamim Shaikh, Yufeng Shen, Amanda D. Shocklee, Andrea R. Simon, Laura Simon, Vini Singh, Steve Skinner, Christopher J. Smith, Kaitlin Smith, LeeAnne G. Snyder, Latha V. Soorya, Aubrie Soucy, Alexandra N. Stephens, Colleen M. Stock, James S. Sutcliffe, James S. Sutcliffe, Amy Swanson, Maira Tafolla, Nicole Takahashi, Carrie Thomas, Taylor Thomas, Samantha Thompson, Jennifer Tjernagel, Tychele N. Turner, Bonnie Van Metre, Jeremy Veenstra-Vanderweele, Brianna M. Vernoia, Natalia Volfovsky, Jermel Wallace, Corrie H. Walston, Jiayao Wang, Tianyun Wang, Zachary Warren, Lucy Wasserburg, Loran Casey White, Sabrina White, Ericka L. Wodka, Simon Xu, Wha S. Yang, Meredith Yinger, Timothy Yu, Lan Zang, Hana Zaydens, Haicang Zhang, Haoquan Zhao, Xueya Zhou
bioRxiv 516625; doi: https://doi.org/10.1101/516625
Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes
Pamela Feliciano, Xueya Zhou, Irina Astrovskaya, Tychele N. Turner, Tianyun Wang, Leo Brueggeman, Rebecca Barnard, Alexander Hsieh, LeeAnne Green Snyder, Donna M. Muzny, Aniko Sabo, The SPARK Consortium, Richard A. Gibbs, Evan E. Eichler, Brian J. O’Roak, Jacob J. Michaelson, Natalia Volfovsky, Yufeng Shen, Wendy K. Chung, Leonard Abbeduto, John Acampado, Andrea J. Ace, Charles Albright, Michael Alessandri, David G. Amaral, Alpha Amatya, Robert D. Annett, Ivette Arriaga, Irina Astrovskaya, Ethan Bahl, Adithya Balasubramanian, Nicole Bardett, Rebecca A. Barnard, Asif Bashar, Arthur Beaudet, Landon Beeson, Raphael A. Bernier, Elizabeth Berry-Kravis, Stephanie Booker, Stephanie J. Brewster, Elizabeth Brooks, Leo Brueggeman, Martin E. Butler, Eric M. Butter, Kristen Callahan, Alexies Camba, Sarah Carpenter, Nicholas Carriero, Lindsey A. Cartner, Ahmad S. Chatha, Wubin Chin, Wendy K. Chung, Renee D. Clark, Cheryl Cohen, Eric Courchesne, Joseph F. Cubells, Mary Hannah Currin, Amy M. Daniels, Lindsey DeMarco, Megan Y. Dennis, Gabriel S. Dichter, Yan Ding, Huyen Dinh, Ryan Doan, HarshaVardhan Doddapaneni, Evan E. Eichler, Sara Eldred, Christine Eng, Craig A. Erickson, Amy Esler, Ali Fatemi, Pamela Feliciano, Gregory Fischer, Ian Fisk, Eric J. Fombonne, Emily A. Fox, Sunday Francis, Sandra L. Friedman, Swami Ganesan, Michael Garrett, Vahid Gazestani, Madeleine R. Geisheker, Jennifer A. Gerdts, Daniel H. Geschwind, Richard A. Gibbs, Robin P. Goin-Kochel, Anthony J.Griswold, Luke P. Grosvenor, Angela J. Gruber, Amanda C. Gulsrud, Jaclyn Gunderson, Anibal Gutierrez, Melissa N. Hale, Monica Haley, Jacob B. Hall, Kira E. Hamer, Bing Han, Nathan Hanna, Christina Harkins, Nina Harris, Brenda Hauf, Caitlin Hayes, Susan L. Hepburn, Lynette M. Herbert, Michelle Heyman, Brittani A. Hilscher, Susannah Horner, Alexander Hsieh, Jianhong Hu, Lark Y. Huang-Storms, Hanna Hutter, Dalia Istephanous, Suma Jacob, William Jensen, Mark Jones, Michelle Jordy, A. Pablo Juarez, Stephen Kanne, Hannah E. Kaplan, Matt Kent, Alex Kitaygorodsky, Tanner Koomar, Viktoriya Korchina, Anthony D. Krentz, Hoa Lam Schneider, Elena Lamarche, Rebecca J. Landa, Alex E. Lash, J. Kiely Law, Noah Lawson, Kevin Layman, Holly Lechniak, Sandra Lee, Soo J. Lee, Daniel Lee Coury, Christa Lese Martin, Hai Li, Deana Li, Natasha Lillie, Xiuping Liu, Catherine Lord, Malcolm D. Mallardi, Patricia Manning, Julie Manoharan, Richard Marini, Gabriela Marzano, Andrew Mason, Emily T. Matthews, James T. McCracken, Alexander P. McKenzie, Jacob J. Michaelson, Zeineen Momin, Michael J. Morrier, Shwetha Murali, Donna Muzny, Vincent J. Myers, Jason Neely, Caitlin Nessner, Amy Nicholson, Kaela O’Brien, Eirene O’Connor, Brian J. O’Roak, Cesar Ochoa-Lubinoff, Jessica Orobio, Opal Y. Ousley, Lillian D. Pacheco, Juhi Pandey, Anna Marie Paolicelli, Katherine G. Pawlowski, Karen L. Pierce, Joseph Piven, Samantha Plate, Marc Popp, Tiziano Pramparo, Lisa M. Prock, Hongjian Qi, Shanping Qiu, Angela L. Rachubinski, Kshitij Rajbhandari, Rishiraj Rana, Rick Remington, Catherine E. Rice, Chris Rigby, Beverly E. Robertson, Katherine Roeder, Cordelia R. Rosenberg, Nicole Russo-Ponsaran, Elizabeth Ruzzo, Aniko Sabo, Mustafa Sahin, Andrei Salomatov, Sophia Sandhu, Susan Santangelo, Dustin E. Sarver, Jessica Scherr, Robert T. Schultz, Kathryn A. Schweers, Swapnil Shah, Tamim Shaikh, Yufeng Shen, Amanda D. Shocklee, Andrea R. Simon, Laura Simon, Vini Singh, Steve Skinner, Christopher J. Smith, Kaitlin Smith, LeeAnne G. Snyder, Latha V. Soorya, Aubrie Soucy, Alexandra N. Stephens, Colleen M. Stock, James S. Sutcliffe, James S. Sutcliffe, Amy Swanson, Maira Tafolla, Nicole Takahashi, Carrie Thomas, Taylor Thomas, Samantha Thompson, Jennifer Tjernagel, Tychele N. Turner, Bonnie Van Metre, Jeremy Veenstra-Vanderweele, Brianna M. Vernoia, Natalia Volfovsky, Jermel Wallace, Corrie H. Walston, Jiayao Wang, Tianyun Wang, Zachary Warren, Lucy Wasserburg, Loran Casey White, Sabrina White, Ericka L. Wodka, Simon Xu, Wha S. Yang, Meredith Yinger, Timothy Yu, Lan Zang, Hana Zaydens, Haicang Zhang, Haoquan Zhao, Xueya Zhou
bioRxiv 516625; doi: https://doi.org/10.1101/516625
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