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Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

View ORCID ProfileAaron M Wenger, Paul Peluso, View ORCID ProfileWilliam J Rowell, Pi-Chuan Chang, View ORCID ProfileRichard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, View ORCID ProfileArmin Toepfer, Michael Alonge, View ORCID ProfileMedhat Mahmoud, View ORCID ProfileYufeng Qian, View ORCID ProfileChen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, View ORCID ProfileJue Ruan, Tobias Marschall, View ORCID ProfileFritz J Sedlazeck, View ORCID ProfileJustin M Zook, View ORCID ProfileHeng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller
doi: https://doi.org/10.1101/519025
Aaron M Wenger
Pacific Biosciences;
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Paul Peluso
Pacific Biosciences;
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William J Rowell
Pacific Biosciences;
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Pi-Chuan Chang
Google Inc.;
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Richard J Hall
Pacific Biosciences;
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Gregory T Concepcion
Pacific Biosciences;
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Jana Ebler
Saarland University, Max Planck Institute for Informatics;
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Arkarachai Fungtammasan
DNAnexus;
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Alexey Kolesnikov
Google Inc.;
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Nathan D Olson
National Institute of Standards and Technology;
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Armin Toepfer
Pacific Biosciences;
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Michael Alonge
Johns Hopkins University;
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Medhat Mahmoud
Baylor College of Medicine;
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Yufeng Qian
Pacific Biosciences;
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Chen-Shan Chin
DNAnexus;
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Adam M Phillippy
National Human Genome Research Institute;
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Michael C Schatz
Johns Hopkins University;
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Gene Myers
Max Planck Institute of Molecular Cell Biology and Genetics;
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Mark A DePristo
Google Inc.;
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Jue Ruan
Chinese Academy of Agriculture Sciences;
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Tobias Marschall
Saarland University, Max Planck Institute for Informatics;
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Fritz J Sedlazeck
Baylor College of Medicine;
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Justin M Zook
National Institute of Standards and Technology;
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Heng Li
Dana-Farber Cancer Institute
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Sergey Koren
National Human Genome Research Institute;
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Andrew Carroll
Google Inc.;
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David R Rank
Pacific Biosciences;
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  • For correspondence: drank@pacificbiosciences.com
Michael W Hunkapiller
Pacific Biosciences;
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Posted January 23, 2019.
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Highly-accurate long-read sequencing improves variant detection and assembly of a human genome
Aaron M Wenger, Paul Peluso, William J Rowell, Pi-Chuan Chang, Richard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, Armin Toepfer, Michael Alonge, Medhat Mahmoud, Yufeng Qian, Chen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, Jue Ruan, Tobias Marschall, Fritz J Sedlazeck, Justin M Zook, Heng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller
bioRxiv 519025; doi: https://doi.org/10.1101/519025
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Highly-accurate long-read sequencing improves variant detection and assembly of a human genome
Aaron M Wenger, Paul Peluso, William J Rowell, Pi-Chuan Chang, Richard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, Armin Toepfer, Michael Alonge, Medhat Mahmoud, Yufeng Qian, Chen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, Jue Ruan, Tobias Marschall, Fritz J Sedlazeck, Justin M Zook, Heng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller
bioRxiv 519025; doi: https://doi.org/10.1101/519025

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