Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

Aaron M Wenger; Paul Peluso; William J Rowell; Pi-Chuan Chang; Richard J Hall; Gregory T Concepcion; Jana Ebler; Arkarachai Fungtammasan; Alexey Kolesnikov; Nathan D Olson; Armin Toepfer; Michael Alonge; Medhat Mahmoud; Yufeng Qian; Chen-Shan Chin; Adam M Phillippy; Michael C Schatz; Gene Myers; Mark A DePristo; Jue Ruan; Tobias Marschall; Fritz J Sedlazeck; Justin M Zook; Heng Li; Sergey Koren; Andrew Carroll; David R Rank; Michael W Hunkapiller

doi:10.1101/519025

New Results

Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

View ORCID ProfileAaron M Wenger, Paul Peluso, View ORCID ProfileWilliam J Rowell, Pi-Chuan Chang, View ORCID ProfileRichard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, View ORCID ProfileArmin Toepfer, Michael Alonge, View ORCID ProfileMedhat Mahmoud, View ORCID ProfileYufeng Qian, View ORCID ProfileChen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, View ORCID ProfileJue Ruan, Tobias Marschall, View ORCID ProfileFritz J Sedlazeck, View ORCID ProfileJustin M Zook, View ORCID ProfileHeng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller

doi: https://doi.org/10.1101/519025

Aaron M Wenger

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Aaron M Wenger

Paul Peluso

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

William J Rowell

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for William J Rowell

Pi-Chuan Chang

Google Inc.;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Richard J Hall

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Richard J Hall

Gregory T Concepcion

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jana Ebler

Saarland University, Max Planck Institute for Informatics;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Arkarachai Fungtammasan

DNAnexus;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alexey Kolesnikov

Google Inc.;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nathan D Olson

National Institute of Standards and Technology;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Armin Toepfer

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Armin Toepfer

Michael Alonge

Johns Hopkins University;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Medhat Mahmoud

Baylor College of Medicine;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Medhat Mahmoud

Yufeng Qian

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yufeng Qian

Chen-Shan Chin

DNAnexus;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chen-Shan Chin

Adam M Phillippy

National Human Genome Research Institute;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael C Schatz

Johns Hopkins University;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gene Myers

Max Planck Institute of Molecular Cell Biology and Genetics;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mark A DePristo

Google Inc.;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jue Ruan

Chinese Academy of Agriculture Sciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jue Ruan

Tobias Marschall

Saarland University, Max Planck Institute for Informatics;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Fritz J Sedlazeck

Baylor College of Medicine;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fritz J Sedlazeck

Justin M Zook

National Institute of Standards and Technology;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Justin M Zook

Heng Li

Dana-Farber Cancer Institute

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Heng Li

Sergey Koren

National Human Genome Research Institute;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrew Carroll

Google Inc.;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David R Rank

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: drank@pacificbiosciences.com

Michael W Hunkapiller

Pacific Biosciences;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Abstract
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: January 2019 to February 2019

	Abstract	Pdf
Jan 2019	7890	3182
Feb 2019	1410	826

View the discussion thread.

PreviousNext

Posted January 23, 2019.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

Aaron M Wenger, Paul Peluso, William J Rowell, Pi-Chuan Chang, Richard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, Armin Toepfer, Michael Alonge, Medhat Mahmoud, Yufeng Qian, Chen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, Jue Ruan, Tobias Marschall, Fritz J Sedlazeck, Justin M Zook, Heng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller

bioRxiv 519025; doi: https://doi.org/10.1101/519025

Share This Article: