Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

Aaron M Wenger; Paul Peluso; William J Rowell; Pi-Chuan Chang; Richard J Hall; Gregory T Concepcion; Jana Ebler; Arkarachai Fungtammasan; Alexey Kolesnikov; Nathan D Olson; Armin Toepfer; Michael Alonge; Medhat Mahmoud; Yufeng Qian; Chen-Shan Chin; Adam M Phillippy; Michael C Schatz; Gene Myers; Mark A DePristo; Jue Ruan; Tobias Marschall; Fritz J Sedlazeck; Justin M Zook; Heng Li; Sergey Koren; Andrew Carroll; David R Rank; Michael W Hunkapiller

doi:10.1101/519025

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Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

View ORCID ProfileAaron M Wenger, Paul Peluso, View ORCID ProfileWilliam J Rowell, Pi-Chuan Chang, View ORCID ProfileRichard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, View ORCID ProfileArmin Toepfer, Michael Alonge, View ORCID ProfileMedhat Mahmoud, View ORCID ProfileYufeng Qian, View ORCID ProfileChen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, View ORCID ProfileJue Ruan, Tobias Marschall, View ORCID ProfileFritz J Sedlazeck, View ORCID ProfileJustin M Zook, View ORCID ProfileHeng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller

doi: https://doi.org/10.1101/519025

Aaron M Wenger

Pacific Biosciences;

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Paul Peluso

Pacific Biosciences;

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William J Rowell

Pacific Biosciences;

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Pi-Chuan Chang

Google Inc.;

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Richard J Hall

Pacific Biosciences;

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Gregory T Concepcion

Pacific Biosciences;

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Jana Ebler

Saarland University, Max Planck Institute for Informatics;

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Arkarachai Fungtammasan

DNAnexus;

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Alexey Kolesnikov

Google Inc.;

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Nathan D Olson

National Institute of Standards and Technology;

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Armin Toepfer

Pacific Biosciences;

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Michael Alonge

Johns Hopkins University;

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Medhat Mahmoud

Baylor College of Medicine;

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Yufeng Qian

Pacific Biosciences;

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Chen-Shan Chin

DNAnexus;

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Adam M Phillippy

National Human Genome Research Institute;

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Michael C Schatz

Johns Hopkins University;

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Gene Myers

Max Planck Institute of Molecular Cell Biology and Genetics;

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Mark A DePristo

Google Inc.;

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Jue Ruan

Chinese Academy of Agriculture Sciences;

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Tobias Marschall

Saarland University, Max Planck Institute for Informatics;

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Fritz J Sedlazeck

Baylor College of Medicine;

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Justin M Zook

National Institute of Standards and Technology;

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Heng Li

Dana-Farber Cancer Institute

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Sergey Koren

National Human Genome Research Institute;

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Andrew Carroll

Google Inc.;

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David R Rank

Pacific Biosciences;

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For correspondence: drank@pacificbiosciences.com

Michael W Hunkapiller

Pacific Biosciences;

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Posted January 23, 2019.

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Highly-accurate long-read sequencing improves variant detection and assembly of a human genome

Aaron M Wenger, Paul Peluso, William J Rowell, Pi-Chuan Chang, Richard J Hall, Gregory T Concepcion, Jana Ebler, Arkarachai Fungtammasan, Alexey Kolesnikov, Nathan D Olson, Armin Toepfer, Michael Alonge, Medhat Mahmoud, Yufeng Qian, Chen-Shan Chin, Adam M Phillippy, Michael C Schatz, Gene Myers, Mark A DePristo, Jue Ruan, Tobias Marschall, Fritz J Sedlazeck, Justin M Zook, Heng Li, Sergey Koren, Andrew Carroll, David R Rank, Michael W Hunkapiller

bioRxiv 519025; doi: https://doi.org/10.1101/519025

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