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A 3D-printed hand-powered centrifuge for molecular biology

View ORCID ProfileGaurav Byagathvalli, View ORCID ProfileAaron F. Pomerantz, Soham Sinha, View ORCID ProfileJanet Standeven, View ORCID ProfileM. Saad Bhamla
doi: https://doi.org/10.1101/519835
Gaurav Byagathvalli
1Lambert High School, 805 Nichols Rd, Suwanee, GA, 30024, USA
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  • For correspondence: saadb@chbe.gatech.edu
Aaron F. Pomerantz
2Department of Integrative Biology, University of California, Berkeley, CA, USA
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  • For correspondence: saadb@chbe.gatech.edu
Soham Sinha
3School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA
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Janet Standeven
1Lambert High School, 805 Nichols Rd, Suwanee, GA, 30024, USA
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M. Saad Bhamla
3School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA
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Abstract

The centrifuge is an essential tool for many aspects of research and medical diagnostics. However, conventional centrifuges are often inaccessible outside of conventional laboratory settings, such as remote field sites, require a constant external power source, and can be prohibitively costly in resource-limited settings and STEM-focused programs. Here we present the 3D-Fuge, a 3D-printed hand-powered centrifuge, as a novel alternative to standard benchtop centrifuges. Based on the design principles of a paper-based centrifuge, this 3D-printed instrument increases the volume capacity to 2 mL and can reach hand-powered centrifugation speeds up to 6,000 rpm. The 3D-Fuge devices presented here are capable of centrifugation of a wide variety of different solutions such as spinning down samples for biomarker applications and performing nucleotide extractions as part of a portable molecular lab setup. We introduce the design and proof-of-principle trials that demonstrate the utility of low-cost 3D printed centrifuges for use in remote and educational settings.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 16, 2019.
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A 3D-printed hand-powered centrifuge for molecular biology
Gaurav Byagathvalli, Aaron F. Pomerantz, Soham Sinha, Janet Standeven, M. Saad Bhamla
bioRxiv 519835; doi: https://doi.org/10.1101/519835
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A 3D-printed hand-powered centrifuge for molecular biology
Gaurav Byagathvalli, Aaron F. Pomerantz, Soham Sinha, Janet Standeven, M. Saad Bhamla
bioRxiv 519835; doi: https://doi.org/10.1101/519835

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