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Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
View ORCID ProfileMax Lam, W. David Hill, Joey W. Trampush, Jin Yu, Emma Knowles, Gail Davies, Eli Stahl, Laura Huckins, David C. Liewald, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J. Lundervold, Vidar M. Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Johan G. Eriksson, Ina Giegling, Bettina Konte, Annette M. Hartmann, Panos Roussos, Stella Giakoumaki, Katherine E. Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K. Attix, Anna C. Need, Elizabeth T. Cirulli, Aristotle N. Voineskos, Nikos C. Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E. Arking, Nikolaos Smyrnis, Robert M. Bilder, Nelson A. Freimer, Tyrone D. Cannon, Edythe London, Russell A. Poldrack, Fred W. Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A. Scult, Dwight Dickinson, Richard E. Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R. Hariri, Daniel R. Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C. Keller, Ole A. Andreassen, Ian J. Deary, David C. Glahn, Anil K. Malhotra, Todd Lencz
doi: https://doi.org/10.1101/519967
Max Lam
1Institute of Mental Health, Singapore
2Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
3Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA
W. David Hill
4Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
5Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Joey W. Trampush
6Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA
Jin Yu
2Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Emma Knowles
7Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Gail Davies
4Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
5Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Eli Stahl
8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
9Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Laura Huckins
8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
9Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
David C. Liewald
5Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Srdjan Djurovic
10Department of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, Norway
11NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Ingrid Melle
11NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
12Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Kjetil Sundet
12Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
13Department of Psychology, University of Oslo, Oslo, Norway
Andrea Christoforou
14Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Ivar Reinvang
13Department of Psychology, University of Oslo, Oslo, Norway
Pamela DeRosse
2Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Astri J. Lundervold
15Department of Biological and Medical Psychology, University of Bergen, Norway
Vidar M. Steen
11NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
14Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Thomas Espeseth
12Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
13Department of Psychology, University of Oslo, Oslo, Norway
Katri Räikkönen
16Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
Elisabeth Widen
17Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Aarno Palotie
17Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
18Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
19Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland
Johan G. Eriksson
20Department of General Practice, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
21National Institute for Health and Welfare, Helsinki, Finland
22Folkhälsan Research Center, Helsinki, Finland
Ina Giegling
23Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Bettina Konte
23Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Annette M. Hartmann
23Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Panos Roussos
8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
9Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
24Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA
Stella Giakoumaki
25Department of Psychology, University of Crete, Greece
Katherine E. Burdick
8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
24Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA
26Department of Psychiatry - Brigham and Women’s Hospital; Harvard Medical School; Boston MA
Antony Payton
27Division of Informatics, Imaging & Data Sciences, School of Health Sciences, The University of Manchester.
William Ollier
28Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, United Kingdom
29School of Healthcare Sciences, Manchester Metropolitan University, Manchester, United Kingdom
Ornit Chiba-Falek
30Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA
Deborah K. Attix
30Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA
31Psychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, NC, USA
Anna C. Need
32Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
Elizabeth T. Cirulli
33Helix Inc, San Diego, CA, USA
Aristotle N. Voineskos
34Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Nikos C. Stefanis
35Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
36University Mental Health Research Institute, Athens, Greece
37Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Dimitrios Avramopoulos
38Department of Psychiatry, Johns Hopkins University School of Medicine, MD, Baltimore, USA
39McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Alex Hatzimanolis
35Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
36University Mental Health Research Institute, Athens, Greece
37Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Dan E. Arking
39McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Nikolaos Smyrnis
35Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
36University Mental Health Research Institute, Athens, Greece
Robert M. Bilder
40UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Nelson A. Freimer
40UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Tyrone D. Cannon
41Department of Psychology, Yale University, New Haven, CT, USA
Edythe London
40UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Russell A. Poldrack
42Department of Psychology, Stanford University, Palo Alto, CA, USA
Fred W. Sabb
43Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA
Eliza Congdon
40UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Emily Drabant Conley
4423andMe, Inc., Mountain View, CA, USA
Matthew A. Scult
45Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Dwight Dickinson
46Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
Richard E. Straub
47Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Gary Donohoe
49Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Derek Morris
49Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Aiden Corvin
50Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Michael Gill
50Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Ahmad R. Hariri
45Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Daniel R. Weinberger
47Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Neil Pendleton
49Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Panos Bitsios
52Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Dan Rujescu
23Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Jari Lahti
16Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
53Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
Stephanie Le Hellard
11NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
14Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Matthew C. Keller
54Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
Ole A. Andreassen
11NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
12Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
55Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Ian J. Deary
4Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
5Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
David C. Glahn
7Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Anil K. Malhotra
2Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
56Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York
57Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
Todd Lencz
2Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
56Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York
57Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
Posted January 20, 2019.
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
Max Lam, W. David Hill, Joey W. Trampush, Jin Yu, Emma Knowles, Gail Davies, Eli Stahl, Laura Huckins, David C. Liewald, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J. Lundervold, Vidar M. Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Johan G. Eriksson, Ina Giegling, Bettina Konte, Annette M. Hartmann, Panos Roussos, Stella Giakoumaki, Katherine E. Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K. Attix, Anna C. Need, Elizabeth T. Cirulli, Aristotle N. Voineskos, Nikos C. Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E. Arking, Nikolaos Smyrnis, Robert M. Bilder, Nelson A. Freimer, Tyrone D. Cannon, Edythe London, Russell A. Poldrack, Fred W. Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A. Scult, Dwight Dickinson, Richard E. Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R. Hariri, Daniel R. Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C. Keller, Ole A. Andreassen, Ian J. Deary, David C. Glahn, Anil K. Malhotra, Todd Lencz
bioRxiv 519967; doi: https://doi.org/10.1101/519967
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
Max Lam, W. David Hill, Joey W. Trampush, Jin Yu, Emma Knowles, Gail Davies, Eli Stahl, Laura Huckins, David C. Liewald, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J. Lundervold, Vidar M. Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Johan G. Eriksson, Ina Giegling, Bettina Konte, Annette M. Hartmann, Panos Roussos, Stella Giakoumaki, Katherine E. Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K. Attix, Anna C. Need, Elizabeth T. Cirulli, Aristotle N. Voineskos, Nikos C. Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E. Arking, Nikolaos Smyrnis, Robert M. Bilder, Nelson A. Freimer, Tyrone D. Cannon, Edythe London, Russell A. Poldrack, Fred W. Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A. Scult, Dwight Dickinson, Richard E. Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R. Hariri, Daniel R. Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C. Keller, Ole A. Andreassen, Ian J. Deary, David C. Glahn, Anil K. Malhotra, Todd Lencz
bioRxiv 519967; doi: https://doi.org/10.1101/519967
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