Abstract
The fission yeast cell is shaped as a very regular cylinder ending by hemi-spheres at both cell ends. Fission yeast cells elongate during interphase keeping this regular shape, set by a balance between cell wall stiffness and turgor pressure. The central position of the nucleus is used as a spatial cue to assemble a contractile actomyosin ring at the geometric cell center when cells entered mitosis. This ring is used to drive the synthesis of a specific cell wall structure called the division septum. The septum is ultimately the place where the cell wall undergoes a fracture, leaving two closed daughter cells approximately half the mother cell after cytokinesis. We proposed scaling arguments where the radii of curvatures of cell ends influence constraints on the cell wall. This relation predicts that the division site would be located closer to the cell end with the highest radius of curvature. We decided to test experimentally whether altered shapes of cell end actually correlate with a displaced division site, leading to an asymmetric cell division. Our results show that the division site position depends on the radius of curvatures of both ends.