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Cdk1 in germline and the dose of somatic EGFR signaling determine the rate of transit amplification

Purna Sham Gadre, Shambhabi Chatterjee, Bhavna Varshney, Chetan Chandra Joshi, Samir Gupta, Nitin Nitsure, View ORCID ProfileKrishanu Ray
doi: https://doi.org/10.1101/521336
Purna Sham Gadre
Tata Institute of Fundamental Research
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Shambhabi Chatterjee
Tata Institute of Fundamental Research
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Bhavna Varshney
Tata Institute of Fundamental Research
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Chetan Chandra Joshi
Tata Institute of Fundamental Research
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Samir Gupta
Tata Institute of Fundamental Research
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Nitin Nitsure
Tata Institute of Fundamental Research
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Krishanu Ray
Tata Institute of Fundamental Research
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  • ORCID record for Krishanu Ray
  • For correspondence: krishanu@tifr.res.in
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Abstract

Stem cell progeny undergoes a series of mitoses, called transit amplifying (TA) divisions, before terminal differentiation. To quantify the impact of the intrinsic and extrinsic factors regulating the rates of TA divisions, we developed a simplified mathematical model which could predict the periods of the germline divisions from the stage-wise distributions of spermatogonial cysts in Drosophila testis. Analysis of the wild-type data using this model suggested that the cell cycle periods speed up after the second TA division due to shortening of the G1 phases. Further, suppression of the cell cycle checkpoint control in germline and upregulation of the somatic EGFR signaling is estimated to slow-down the rates of both the germline stem cell and TA divisions, increasing the cellular life spans at each stage. Together, these results suggest that higher levels of EGFR activation could attenuate cell division rates in the neighborhood, controlling the extents of tissue growth.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 15, 2019.
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Cdk1 in germline and the dose of somatic EGFR signaling determine the rate of transit amplification
Purna Sham Gadre, Shambhabi Chatterjee, Bhavna Varshney, Chetan Chandra Joshi, Samir Gupta, Nitin Nitsure, Krishanu Ray
bioRxiv 521336; doi: https://doi.org/10.1101/521336
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Cdk1 in germline and the dose of somatic EGFR signaling determine the rate of transit amplification
Purna Sham Gadre, Shambhabi Chatterjee, Bhavna Varshney, Chetan Chandra Joshi, Samir Gupta, Nitin Nitsure, Krishanu Ray
bioRxiv 521336; doi: https://doi.org/10.1101/521336

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