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Cerebellar disruption impairs working memory during evidence accumulation

Ben Deverett, Mikhail Kislin, David W. Tank, Samuel S.-H. Wang
doi: https://doi.org/10.1101/521849
Ben Deverett
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USADepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USARutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
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Mikhail Kislin
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
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David W. Tank
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USADepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
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Samuel S.-H. Wang
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USADepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
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  • For correspondence: sswang@princeton.edu
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Abstract

To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. We found that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduced the accuracy of subsequent memory-guided decisions and caused mice to downweight prior information. Behavioral deficits were consistent with the addition of noise and leak to the evidence accumulation process, suggesting the cerebellum can influence the maintenance of working memory contents.

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Posted January 17, 2019.
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Cerebellar disruption impairs working memory during evidence accumulation
Ben Deverett, Mikhail Kislin, David W. Tank, Samuel S.-H. Wang
bioRxiv 521849; doi: https://doi.org/10.1101/521849
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Cerebellar disruption impairs working memory during evidence accumulation
Ben Deverett, Mikhail Kislin, David W. Tank, Samuel S.-H. Wang
bioRxiv 521849; doi: https://doi.org/10.1101/521849

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