Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Paul C. Moore; Jenny Y. Qi; Maike Thamsen; Rajarshi Ghosh; Justin Peng; Micah J. Gliedt; Rosa Meza-Acevedo; Rachel E. Warren; Annie Hiniker; Grace E. Kim; Dustin J. Maly; Bradley J. Backes; Feroz R. Papa; Scott A. Oakes

doi:10.1101/522102

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Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Paul C. Moore, Jenny Y. Qi, Maike Thamsen, Rajarshi Ghosh, Justin Peng, Micah J. Gliedt, Rosa Meza-Acevedo, Rachel E. Warren, Annie Hiniker, Grace E. Kim, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa, Scott A. Oakes

doi: https://doi.org/10.1101/522102

Paul C. Moore

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Jenny Y. Qi

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Maike Thamsen

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Rajarshi Ghosh

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Justin Peng

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Micah J. Gliedt

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Rosa Meza-Acevedo

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Rachel E. Warren

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Annie Hiniker

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Grace E. Kim

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Dustin J. Maly

7Department of Chemistry, University of Washington, Seattle, WA 98195, U.S.A.

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Bradley J. Backes

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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Feroz R. Papa

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

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For correspondence: feroz.papa@ucsf.edu soakes@bsd.uchicago.edu

Scott A. Oakes

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

8Department of Pathology, Biological Sciences Division, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, U.S.A.

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For correspondence: feroz.papa@ucsf.edu soakes@bsd.uchicago.edu

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