Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Paul C. Moore; Jenny Y. Qi; Maike Thamsen; Rajarshi Ghosh; Justin Peng; Micah J. Gliedt; Rosa Meza-Acevedo; Rachel E. Warren; Annie Hiniker; Grace E. Kim; Dustin J. Maly; Bradley J. Backes; Feroz R. Papa; Scott A. Oakes

doi:10.1101/522102

New Results

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Paul C. Moore, Jenny Y. Qi, Maike Thamsen, Rajarshi Ghosh, Justin Peng, Micah J. Gliedt, Rosa Meza-Acevedo, Rachel E. Warren, Annie Hiniker, Grace E. Kim, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa, Scott A. Oakes

doi: https://doi.org/10.1101/522102

Paul C. Moore

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jenny Y. Qi

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maike Thamsen

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rajarshi Ghosh

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Justin Peng

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Micah J. Gliedt

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rosa Meza-Acevedo

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rachel E. Warren

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Annie Hiniker

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Grace E. Kim

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Dustin J. Maly

7Department of Chemistry, University of Washington, Seattle, WA 98195, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bradley J. Backes

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Feroz R. Papa

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

4Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

5Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

6California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: feroz.papa@ucsf.edu soakes@bsd.uchicago.edu

Scott A. Oakes

1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

3Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, U.S.A.

8Department of Pathology, Biological Sciences Division, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, U.S.A.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: feroz.papa@ucsf.edu soakes@bsd.uchicago.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Supplemental Figure 1[supplements/522102_file02.pdf]
Supplemental Figure 2[supplements/522102_file03.pdf]
Supplemental Figure 3[supplements/522102_file04.pdf]
Supplemental Figure 4[supplements/522102_file05.pdf]
Supplemental Figure 5[supplements/522102_file06.pdf]
Supplemental Figure 6[supplements/522102_file07.pdf]
Supplemental Figure 7[supplements/522102_file08.pdf]
Supplemental Tables 1-3[supplements/522102_file09.pdf]

View the discussion thread.

PreviousNext

Posted September 18, 2019.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

bioRxiv 522102; doi: https://doi.org/10.1101/522102

Share This Article:

Citation Tools

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

bioRxiv 522102; doi: https://doi.org/10.1101/522102

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Cancer Biology

Subject Areas

All Articles

Animal Behavior and Cognition (4237)
Biochemistry (9142)
Bioengineering (6784)
Bioinformatics (24017)
Biophysics (12134)
Cancer Biology (9539)
Cell Biology (13792)
Clinical Trials (138)
Developmental Biology (7639)
Ecology (11713)
Epidemiology (2066)
Evolutionary Biology (15516)
Genetics (10649)
Genomics (14330)
Immunology (9488)
Microbiology (22852)
Molecular Biology (9096)
Neuroscience (49019)
Paleontology (355)
Pathology (1483)
Pharmacology and Toxicology (2570)
Physiology (3848)
Plant Biology (8335)
Scientific Communication and Education (1472)
Synthetic Biology (2296)
Systems Biology (6194)
Zoology (1302)