Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Thalamus drives two complementary input strata of the neocortex in parallel

R. Egger, R.T. Narayanan, D. Udvary, A. Bast, J.M. Guest, S. Das, C.P.J. de Kock, M. Oberlaender
doi: https://doi.org/10.1101/524298
R. Egger
1Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R.T. Narayanan
1Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Udvary
1Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Bast
1Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.M. Guest
1Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Das
2Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.P.J. de Kock
2Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Oberlaender
1Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: marcel.oberlaender@caesar.de
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Sensory information enters the neocortex via thalamocortical axons that define the major ‘input’ layer 4. The same thalamocortical axons, however, additionally innervate the deep ‘output’ layers 5/6. How such bistratification impacts cortical processing remains unknown. Here, we find a class of neurons that cluster specifically around thalamocortical axons at the layer 5/6 border. We show that these border stratum cells are characterized by extensive horizontal axons, that they receive strong convergent input from the thalamus, and that this input is sufficient to drive reliable sensory-evoked responses, which precede those in layer 4. These cells are hence strategically placed to amplify and relay thalamocortical inputs across the cortical area, for example to drive the fast onsets of cortical output patterns. Layer 4 is therefore not the sole starting point of cortical processing. Instead, parallel activation of layer 4 and the border stratum is necessary to broadcast information out of the neocortex.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted January 18, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Thalamus drives two complementary input strata of the neocortex in parallel
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Thalamus drives two complementary input strata of the neocortex in parallel
R. Egger, R.T. Narayanan, D. Udvary, A. Bast, J.M. Guest, S. Das, C.P.J. de Kock, M. Oberlaender
bioRxiv 524298; doi: https://doi.org/10.1101/524298
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Thalamus drives two complementary input strata of the neocortex in parallel
R. Egger, R.T. Narayanan, D. Udvary, A. Bast, J.M. Guest, S. Das, C.P.J. de Kock, M. Oberlaender
bioRxiv 524298; doi: https://doi.org/10.1101/524298

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3505)
  • Biochemistry (7348)
  • Bioengineering (5324)
  • Bioinformatics (20266)
  • Biophysics (10020)
  • Cancer Biology (7744)
  • Cell Biology (11305)
  • Clinical Trials (138)
  • Developmental Biology (6437)
  • Ecology (9953)
  • Epidemiology (2065)
  • Evolutionary Biology (13325)
  • Genetics (9361)
  • Genomics (12586)
  • Immunology (7702)
  • Microbiology (19024)
  • Molecular Biology (7443)
  • Neuroscience (41041)
  • Paleontology (300)
  • Pathology (1229)
  • Pharmacology and Toxicology (2138)
  • Physiology (3161)
  • Plant Biology (6861)
  • Scientific Communication and Education (1273)
  • Synthetic Biology (1896)
  • Systems Biology (5313)
  • Zoology (1089)