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Evaluating potential drug targets through human loss-of-function genetic variation
View ORCID ProfileEric Vallabh Minikel, View ORCID ProfileKonrad J Karczewski, View ORCID ProfileHilary C Martin, View ORCID ProfileBeryl B Cummings, View ORCID ProfileNicola Whiffin, View ORCID ProfileJessica Alföldi, View ORCID ProfileRichard C Trembath, View ORCID ProfileDavid A van Heel, Mark J Daly, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, View ORCID ProfileStuart L Schreiber, Daniel G MacArthur
doi: https://doi.org/10.1101/530881
Eric Vallabh Minikel
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
3Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA
4Prion Alliance, Cambridge, MA, 02139, USA
Konrad J Karczewski
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
Hilary C Martin
5Wellcome Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK
Beryl B Cummings
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
3Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA
Nicola Whiffin
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
6National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, SW7 2AZ, UK
Jessica Alföldi
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
Richard C Trembath
7Faculty of Life Sciences and Medicine, King’s College London, London, WC2R 2LS, UK
8Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK
David A van Heel
8Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK
Mark J Daly
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
Stuart L Schreiber
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
9Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, 02138, USA
Daniel G MacArthur
1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
2Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA
Article usage
Posted March 15, 2019.
Evaluating potential drug targets through human loss-of-function genetic variation
Eric Vallabh Minikel, Konrad J Karczewski, Hilary C Martin, Beryl B Cummings, Nicola Whiffin, Jessica Alföldi, Richard C Trembath, David A van Heel, Mark J Daly, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Stuart L Schreiber, Daniel G MacArthur
bioRxiv 530881; doi: https://doi.org/10.1101/530881
Evaluating potential drug targets through human loss-of-function genetic variation
Eric Vallabh Minikel, Konrad J Karczewski, Hilary C Martin, Beryl B Cummings, Nicola Whiffin, Jessica Alföldi, Richard C Trembath, David A van Heel, Mark J Daly, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Stuart L Schreiber, Daniel G MacArthur
bioRxiv 530881; doi: https://doi.org/10.1101/530881
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