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Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease
View ORCID ProfileGalen E.B. Wright, Jennifer A. Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Alicia Semaka, Charlotte M. Nguyen, Brett Trost, Fiona Richards, Emilia K. Bijlsma, Ferdinando Squitieri, Stephen W. Scherer, Michael A. Eberle, Ryan K.C. Yuen, View ORCID ProfileMichael R. Hayden
doi: https://doi.org/10.1101/533414
Galen E.B. Wright
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Jennifer A. Collins
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Chris Kay
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Cassandra McDonald
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Egor Dolzhenko
2Illumina Inc, San Diego, California, USA
Qingwen Xia
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Kristina Bečanović
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
3Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Alicia Semaka
4Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Charlotte M. Nguyen
5The Hospital For Sick Children, The Centre for Applied Genomics, Genetics and Genome Biology
6University of Toronto, Department of Molecular Genetics
Brett Trost
5The Hospital For Sick Children, The Centre for Applied Genomics, Genetics and Genome Biology
Fiona Richards
7Department of Clinical Genetics, Children’s Hospital at Westmead
Emilia K. Bijlsma
8Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands
Ferdinando Squitieri
9Huntington and Rare Diseases Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Stephen W. Scherer
5The Hospital For Sick Children, The Centre for Applied Genomics, Genetics and Genome Biology
6University of Toronto, Department of Molecular Genetics
10McLaughlin Centre, University of Toronto.
Michael A. Eberle
2Illumina Inc, San Diego, California, USA
Ryan K.C. Yuen
5The Hospital For Sick Children, The Centre for Applied Genomics, Genetics and Genome Biology
6University of Toronto, Department of Molecular Genetics
Michael R. Hayden
1Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Posted February 07, 2019.
Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease
Galen E.B. Wright, Jennifer A. Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Alicia Semaka, Charlotte M. Nguyen, Brett Trost, Fiona Richards, Emilia K. Bijlsma, Ferdinando Squitieri, Stephen W. Scherer, Michael A. Eberle, Ryan K.C. Yuen, Michael R. Hayden
bioRxiv 533414; doi: https://doi.org/10.1101/533414
Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease
Galen E.B. Wright, Jennifer A. Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Alicia Semaka, Charlotte M. Nguyen, Brett Trost, Fiona Richards, Emilia K. Bijlsma, Ferdinando Squitieri, Stephen W. Scherer, Michael A. Eberle, Ryan K.C. Yuen, Michael R. Hayden
bioRxiv 533414; doi: https://doi.org/10.1101/533414
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