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Life history recorded in the vagino-cervical microbiome

Zhuye Jie, Chen Chen, Lilan Hao, Fei Li, Liju Song, Xiaowei Zhang, Jie Zhu, Liu Tian, Xin Tong, Kaiye Cai, Yanmei Ju, Xinlei Yu, Ying Li, Hongcheng Zhou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Dongsheng Zhou, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Na Liu, Jinghua Wu, Wei Zhang, Xiao Liu, Yang Zong, Weibin Liu, Liang Xiao, Yong Hou, Xun Xu, Huanming Yang, Jian Wang, Karsten Kristiansen, Huijue Jia
doi: https://doi.org/10.1101/533588
Zhuye Jie
1BGI-Shenzhen, Shenzhen 518083, China;
2Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China;
3Department of Biology, Ole Maaløes Vej 5, University of Copenhagen, Copenhagen, Denmark;
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Chen Chen
1BGI-Shenzhen, Shenzhen 518083, China;
2Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China;
3Department of Biology, Ole Maaløes Vej 5, University of Copenhagen, Copenhagen, Denmark;
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  • For correspondence: jiahuijue@genomics.cn chenchen1@genomics.cn
Lilan Hao
1BGI-Shenzhen, Shenzhen 518083, China;
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Fei Li
1BGI-Shenzhen, Shenzhen 518083, China;
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Liju Song
1BGI-Shenzhen, Shenzhen 518083, China;
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Xiaowei Zhang
1BGI-Shenzhen, Shenzhen 518083, China;
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Jie Zhu
1BGI-Shenzhen, Shenzhen 518083, China;
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Liu Tian
1BGI-Shenzhen, Shenzhen 518083, China;
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Xin Tong
1BGI-Shenzhen, Shenzhen 518083, China;
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Kaiye Cai
1BGI-Shenzhen, Shenzhen 518083, China;
4Shenzhen Engineering Laboratory of Detection and Intervention of human intestinal microbiome, BGI-Shenzhen, Shenzhen, China;
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Yanmei Ju
1BGI-Shenzhen, Shenzhen 518083, China;
5BGI Education Center, University of Chinese Academy of Sciences, BGI-Shenzhen, Shenzhen 518083, China;
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Xinlei Yu
1BGI-Shenzhen, Shenzhen 518083, China;
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Ying Li
1BGI-Shenzhen, Shenzhen 518083, China;
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Hongcheng Zhou
6China National Genebank, BGI-Shenzhen, Shenzhen 518120, China;
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Haorong Lu
6China National Genebank, BGI-Shenzhen, Shenzhen 518120, China;
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Xuemei Qiu
1BGI-Shenzhen, Shenzhen 518083, China;
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Qiang Li
1BGI-Shenzhen, Shenzhen 518083, China;
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Yunli Liao
1BGI-Shenzhen, Shenzhen 518083, China;
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Dongsheng Zhou
1BGI-Shenzhen, Shenzhen 518083, China;
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Heng Lian
1BGI-Shenzhen, Shenzhen 518083, China;
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Yong Zuo
1BGI-Shenzhen, Shenzhen 518083, China;
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Xiaomin Chen
1BGI-Shenzhen, Shenzhen 518083, China;
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Weiqiao Rao
1BGI-Shenzhen, Shenzhen 518083, China;
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Yan Ren
1BGI-Shenzhen, Shenzhen 518083, China;
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Yuan Wang
1BGI-Shenzhen, Shenzhen 518083, China;
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Jin Zi
1BGI-Shenzhen, Shenzhen 518083, China;
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Rong Wang
1BGI-Shenzhen, Shenzhen 518083, China;
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Na Liu
1BGI-Shenzhen, Shenzhen 518083, China;
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Jinghua Wu
1BGI-Shenzhen, Shenzhen 518083, China;
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Wei Zhang
1BGI-Shenzhen, Shenzhen 518083, China;
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Xiao Liu
1BGI-Shenzhen, Shenzhen 518083, China;
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Yang Zong
1BGI-Shenzhen, Shenzhen 518083, China;
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Weibin Liu
1BGI-Shenzhen, Shenzhen 518083, China;
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Liang Xiao
1BGI-Shenzhen, Shenzhen 518083, China;
4Shenzhen Engineering Laboratory of Detection and Intervention of human intestinal microbiome, BGI-Shenzhen, Shenzhen, China;
7BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China;
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Yong Hou
1BGI-Shenzhen, Shenzhen 518083, China;
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Xun Xu
1BGI-Shenzhen, Shenzhen 518083, China;
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Huanming Yang
1BGI-Shenzhen, Shenzhen 518083, China;
8James D. Watson Institute of Genome Sciences, Hangzhou, China
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Jian Wang
1BGI-Shenzhen, Shenzhen 518083, China;
8James D. Watson Institute of Genome Sciences, Hangzhou, China
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Karsten Kristiansen
1BGI-Shenzhen, Shenzhen 518083, China;
3Department of Biology, Ole Maaløes Vej 5, University of Copenhagen, Copenhagen, Denmark;
7BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China;
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Huijue Jia
1BGI-Shenzhen, Shenzhen 518083, China;
2Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China;
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  • For correspondence: jiahuijue@genomics.cn chenchen1@genomics.cn
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SUMMARY

The vagina contains at least a billion microbial cells, which are dominated by Lactobacilli. Here we perform metagenomic shotgun sequencing on cervical samples from 1148 women. Factors such as pregnancy, delivery histories and breast-feeding were all more important than menstrual cycle in shaping the microbiome. Bifidobacterium breve was seen with older age at sexual debut; Lactobacillus crispatus negatively correlated with pregnancy history; potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, contraceptives were also identified. Other features such as mood fluctuations and facial speckles could potentially be deduced from the vagino-cervical microbiome. Gut and oral microbiome, plasma vitamins, metals, amino acids and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact.

Highlights Shotgun sequencing of 1148 vagino-cervical samples reveal subtypes;

Other omics such as moods and skin features could be predicted by the vagino-cervical bacteria;

Factors such as delivery mode and breast-feeding associate with the vagino-cervical microbiome;

With dwindled Lactobacilli, postmenopausal samples are relatively enriched for viruses.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 04, 2019.
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Life history recorded in the vagino-cervical microbiome
Zhuye Jie, Chen Chen, Lilan Hao, Fei Li, Liju Song, Xiaowei Zhang, Jie Zhu, Liu Tian, Xin Tong, Kaiye Cai, Yanmei Ju, Xinlei Yu, Ying Li, Hongcheng Zhou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Dongsheng Zhou, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Na Liu, Jinghua Wu, Wei Zhang, Xiao Liu, Yang Zong, Weibin Liu, Liang Xiao, Yong Hou, Xun Xu, Huanming Yang, Jian Wang, Karsten Kristiansen, Huijue Jia
bioRxiv 533588; doi: https://doi.org/10.1101/533588
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Life history recorded in the vagino-cervical microbiome
Zhuye Jie, Chen Chen, Lilan Hao, Fei Li, Liju Song, Xiaowei Zhang, Jie Zhu, Liu Tian, Xin Tong, Kaiye Cai, Yanmei Ju, Xinlei Yu, Ying Li, Hongcheng Zhou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Dongsheng Zhou, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Na Liu, Jinghua Wu, Wei Zhang, Xiao Liu, Yang Zong, Weibin Liu, Liang Xiao, Yong Hou, Xun Xu, Huanming Yang, Jian Wang, Karsten Kristiansen, Huijue Jia
bioRxiv 533588; doi: https://doi.org/10.1101/533588

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