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The anterior insula channels prefrontal expectancy signals during affective processing

View ORCID ProfileVanessa Teckentrup, View ORCID ProfileJohan N. van der Meer, View ORCID ProfileViola Borchardt, Yan Fan, View ORCID ProfileMonja P. Neuser, View ORCID ProfileClaus Tempelmann, Luisa Herrmann, View ORCID ProfileMartin Walter, View ORCID ProfileNils B. Kroemer
doi: https://doi.org/10.1101/536300
Vanessa Teckentrup
1University of Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany
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  • ORCID record for Vanessa Teckentrup
Johan N. van der Meer
2Queensland Institute of Medical Research, Brisbane, Australia
3University of Magdeburg, Department of Psychiatry and Psychotherapy, Germany
4Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany
5Leibniz Institute for Neurobiology, Magdeburg, Germany
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Viola Borchardt
4Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany
5Leibniz Institute for Neurobiology, Magdeburg, Germany
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Yan Fan
6Leibniz Research Centre for Working Environment and Human Factors, Department of Psychology and Neurosciences Dortmund, German
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Monja P. Neuser
1University of Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany
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Claus Tempelmann
7University of Magdeburg, Department of Neurology, Germany
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Luisa Herrmann
1University of Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany
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Martin Walter
1University of Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany
3University of Magdeburg, Department of Psychiatry and Psychotherapy, Germany
4Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany
5Leibniz Institute for Neurobiology, Magdeburg, Germany
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  • For correspondence: martin.walter@uni-tuebingen.de nils.kroemer@uni-tuebingen.de
Nils B. Kroemer
1University of Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany
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  • For correspondence: martin.walter@uni-tuebingen.de nils.kroemer@uni-tuebingen.de
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Abstract

Expectancy shapes our perception of impending events. Although such an interplay between cognitive and affective processes is often impaired in mental disorders, it is not well understood how top-down expectancy signals modulate future affect. We therefore track the information flow in the brain during cognitive and affective processing segregated in time using task-specific cross-correlations. Participants in two independent fMRI studies (N1 = 37 & N2 = 55) were instructed to imagine a situation with affective content as indicated by a cue, which was then followed by an emotional picture congruent with expectancy. To correct for intrinsic covariance of brain function, we calculate resting-state cross-correlations analogous to the task. First, using factorial modeling of delta cross-correlations (task-rest) of the first study, we find that the magnitude of expectancy signals in the anterior insula cortex (AIC) modulates the BOLD response to emotional pictures in the anterior cingulate and dorsomedial prefrontal cortex in opposite directions. Second, using hierarchical linear modeling of lagged connectivity, we demonstrate that expectancy signals in the AIC indeed foreshadow this opposing pattern in the prefrontal cortex. Third, we replicate the results in the second study using a higher temporal resolution, showing that our task-specific cross-correlation approach robustly uncovers the dynamics of information flow. We conclude that the AIC arbitrates the recruitment of distinct prefrontal networks during cued picture processing according to triggered expectations. Taken together, our study provides new insights into neuronal pathways channeling cognition and affect within well-defined brain networks. Better understanding of such dynamics could lead to new applications tracking aberrant information processing in mental disorders.

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Posted February 04, 2019.
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The anterior insula channels prefrontal expectancy signals during affective processing
Vanessa Teckentrup, Johan N. van der Meer, Viola Borchardt, Yan Fan, Monja P. Neuser, Claus Tempelmann, Luisa Herrmann, Martin Walter, Nils B. Kroemer
bioRxiv 536300; doi: https://doi.org/10.1101/536300
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The anterior insula channels prefrontal expectancy signals during affective processing
Vanessa Teckentrup, Johan N. van der Meer, Viola Borchardt, Yan Fan, Monja P. Neuser, Claus Tempelmann, Luisa Herrmann, Martin Walter, Nils B. Kroemer
bioRxiv 536300; doi: https://doi.org/10.1101/536300

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