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The Arabidopsis thaliana pan-NLRome

View ORCID ProfileAnna-Lena Van de Weyer, View ORCID ProfileFreddy Monteiro, View ORCID ProfileOliver J. Furzer, View ORCID ProfileMarc T. Nishimura, View ORCID ProfileVolkan Cevik, View ORCID ProfileKamil Witek, View ORCID ProfileJonathan D.G. Jones, View ORCID ProfileJeffery L. Dangl, View ORCID ProfileDetlef Weigel, View ORCID ProfileFelix Bemm
doi: https://doi.org/10.1101/537001
Anna-Lena Van de Weyer
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
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  • ORCID record for Anna-Lena Van de Weyer
Freddy Monteiro
2Howard Hughes Medical Institute and Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA
3Center for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, 08193 Barcelona, Spain
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Oliver J. Furzer
2Howard Hughes Medical Institute and Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA
5The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
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Marc T. Nishimura
4Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
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Volkan Cevik
5The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
6The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, United Kingdom
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Kamil Witek
5The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
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Jonathan D.G. Jones
5The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
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  • For correspondence: jonathan.jones@tsl.ac.uk dangl@email.unc.edu weigel@weigelworld.org
Jeffery L. Dangl
2Howard Hughes Medical Institute and Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA
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  • ORCID record for Jeffery L. Dangl
  • For correspondence: jonathan.jones@tsl.ac.uk dangl@email.unc.edu weigel@weigelworld.org
Detlef Weigel
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
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  • For correspondence: jonathan.jones@tsl.ac.uk dangl@email.unc.edu weigel@weigelworld.org
Felix Bemm
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
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Abstract

Disease is both among the most important selection pressures in nature and among the main causes of yield loss in agriculture. In plants, resistance to disease is often conferred by Nucleotide-binding Leucine-rich Repeat (NLR) proteins. These proteins function as intracellular immune receptors that recognize pathogen proteins and their effects on the plant. Consistent with evolutionarily dynamic interactions between plants and pathogens, NLRs are known to be encoded by one of the most variable gene families in plants, but the true extent of intraspecific NLR diversity has been unclear. Here, we define the majority of the Arabidopsis thaliana species-wide “NLRome”. From NLR sequence enrichment and long-read sequencing of 65 diverse A. thaliana accessions, we infer that the pan-NLRome saturates with approximately 40 accessions. Despite the high diversity of NLRs, half of the pan-NLRome is present in most accessions. We chart the architectural diversity of NLR proteins, identify novel architectures, and quantify the selective forces that act on specific NLRs, domains, and positions. Our study provides a blueprint for defining the pan-NLRome of plant species.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 31, 2019.
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The Arabidopsis thaliana pan-NLRome
Anna-Lena Van de Weyer, Freddy Monteiro, Oliver J. Furzer, Marc T. Nishimura, Volkan Cevik, Kamil Witek, Jonathan D.G. Jones, Jeffery L. Dangl, Detlef Weigel, Felix Bemm
bioRxiv 537001; doi: https://doi.org/10.1101/537001
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The Arabidopsis thaliana pan-NLRome
Anna-Lena Van de Weyer, Freddy Monteiro, Oliver J. Furzer, Marc T. Nishimura, Volkan Cevik, Kamil Witek, Jonathan D.G. Jones, Jeffery L. Dangl, Detlef Weigel, Felix Bemm
bioRxiv 537001; doi: https://doi.org/10.1101/537001

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