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“Multiple human adipocyte subtypes and mechanisms of their development”

So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Ryan M.J. Genga, View ORCID ProfileAlper Kucukural, Lawrence Lifshitz, View ORCID ProfileRené Maehr, View ORCID ProfileManuel Garber, View ORCID ProfileSilvia Corvera
doi: https://doi.org/10.1101/537464
So Yun Min
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
2Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Anand Desai
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Zinger Yang
2Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Agastya Sharma
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Ryan M.J. Genga
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
2Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA
4Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Alper Kucukural
3Program in Bioinformatics, University of Massachusetts Medical School, Worcester, MA 01655, USA
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  • ORCID record for Alper Kucukural
Lawrence Lifshitz
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
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René Maehr
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
4Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01655, USA
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  • ORCID record for René Maehr
Manuel Garber
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
3Program in Bioinformatics, University of Massachusetts Medical School, Worcester, MA 01655, USA
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  • ORCID record for Manuel Garber
Silvia Corvera
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
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  • ORCID record for Silvia Corvera
  • For correspondence: silvia.corvera@umassmed.edu
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SUMMARY

Human adipose tissue depots perform numerous diverse physiological functions, and are differentially linked to metabolic disease risk, yet only two major human adipocyte subtypes have been described, white and “brown/brite/beige.” The diversity and lineages of adipocyte classes have been studied in mice using genetic methods that cannot be applied in humans. Here we circumvent this problem by studying the fate of single mesenchymal progenitor cells obtained from human adipose tissue. We report that a minimum of four human adipocyte subtypes can be distinguished by transcriptomic analysis, specialized for functionally distinct processes such as adipokine secretion and thermogenesis. Evidence for the presence of these adipocytes subtypes in adult humans is evidenced by differential expression of key adipokines leptin and adiponectin in isolated mature adipocytes. The human adipocytes most similar to the mouse “brite/beige” adipocytes are enriched in mechanisms that promote iron accumulation and protect from oxidative stress, and are derived from progenitors that express high levels of cytokines such as IL1B, IL8, IL11 and the IL6 family cytokine LIF, and low levels of the transcriptional repressors ID1 and ID3. Our finding of this adipocyte repertoire and its developmental mechanisms provides a high-resolution framework to analyze human adipose tissue architecture and its role in systemic metabolism and metabolic disease.

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Posted January 31, 2019.
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“Multiple human adipocyte subtypes and mechanisms of their development”
So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Ryan M.J. Genga, Alper Kucukural, Lawrence Lifshitz, René Maehr, Manuel Garber, Silvia Corvera
bioRxiv 537464; doi: https://doi.org/10.1101/537464
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“Multiple human adipocyte subtypes and mechanisms of their development”
So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Ryan M.J. Genga, Alper Kucukural, Lawrence Lifshitz, René Maehr, Manuel Garber, Silvia Corvera
bioRxiv 537464; doi: https://doi.org/10.1101/537464

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