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Peripheral axonal ensheathment is regulated by Ral GTPase and the exocyst complex

Joana F. Silva-Rodrigues, Cátia F. Patrício-Rodrigues, Vicente de Sousa-Xavier, Pedro M. Augusto, Ana C. Fernandes, Ana R. Farinho, Rita O. Teodoro
doi: https://doi.org/10.1101/537969
Joana F. Silva-Rodrigues
1Neuronal Growth and Plasticity Lab CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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Cátia F. Patrício-Rodrigues
1Neuronal Growth and Plasticity Lab CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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Vicente de Sousa-Xavier
1Neuronal Growth and Plasticity Lab CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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Pedro M. Augusto
1Neuronal Growth and Plasticity Lab CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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Ana C. Fernandes
1Neuronal Growth and Plasticity Lab CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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Ana R. Farinho
2Histology Facility, CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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Rita O. Teodoro
1Neuronal Growth and Plasticity Lab CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
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  • For correspondence: rita.teodoro@nms.unl.pt
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Abstract

Axon ensheathment is fundamental for fast impulse conduction and the normal physiological functioning of the nervous system. Defects in axonal insulation lead to debilitating conditions, but despite its importance, the molecular players responsible are poorly defined. Here, we identify Ral GTPase as a key player in axon ensheathment in Drosophila larval peripheral nerves. We demonstrate through genetic analysis that Ral action through the exocyst complex is sufficient and necessary in wrapping glial cells to regulate their growth and development. We suggest that the Ral-exocyst pathway controls the targeting of secretory vesicles for membrane growth or for the secretion of a wrapping glia-specific factor that itself regulates growth. In summary, our findings provide a new molecular understanding of the process by which axons are ensheathed in vivo, a process critical for normal neuronal function.

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Posted February 01, 2019.
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Peripheral axonal ensheathment is regulated by Ral GTPase and the exocyst complex
Joana F. Silva-Rodrigues, Cátia F. Patrício-Rodrigues, Vicente de Sousa-Xavier, Pedro M. Augusto, Ana C. Fernandes, Ana R. Farinho, Rita O. Teodoro
bioRxiv 537969; doi: https://doi.org/10.1101/537969
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Peripheral axonal ensheathment is regulated by Ral GTPase and the exocyst complex
Joana F. Silva-Rodrigues, Cátia F. Patrício-Rodrigues, Vicente de Sousa-Xavier, Pedro M. Augusto, Ana C. Fernandes, Ana R. Farinho, Rita O. Teodoro
bioRxiv 537969; doi: https://doi.org/10.1101/537969

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