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A familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene affects brain energy production

View ORCID ProfileMorgan Newman, View ORCID ProfileNhi Hin, View ORCID ProfileStephen M Pederson, View ORCID ProfileMichael Lardelli
doi: https://doi.org/10.1101/542134
Morgan Newman
The University of Adelaide;
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  • For correspondence: morgan.newman@adelaide.edu.au
Nhi Hin
University of Adelaide
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  • For correspondence: nhi.hin@adelaide.edu.au
Stephen M Pederson
The University of Adelaide;
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  • For correspondence: stephen.pederson@adelaide.edu.au
Michael Lardelli
University of Adelaide
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  • For correspondence: michael.lardelli@adelaide.edu.au
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Abstract

To prevent or ameliorate Alzheimer's disease (AD) we must understand its molecular basis. AD develops over decades but detailed molecular analysis of AD brains is limited to postmortem tissue where the stresses initiating the disease may be obscured by compensatory responses and neurodegenerative processes. Rare, dominant mutations in a small number of genes, but particularly the gene PRESENILIN 1 (PSEN1), drive early onset of familial AD (EOfAD). Numerous transgenic models of AD have been constructed in mouse and other organisms, but transcriptomic analysis of these models has raised serious doubts regarding their representation of the disease state. Since we lack clarity regarding the molecular mechanism(s) underlying AD, we posit that the most valid approach is to model the human EOfAD genetic state as closely as possible. Therefore, we sought to analyse brains from zebrafish heterozygous for a single, EOfAD-like mutation in their PSEN1-orthologous gene, psen1. We previously introduced an EOfAD-like mutation (Q96_K97del) into the endogenous psen1 gene of zebrafish. Here, we analysed transcriptomes of young adult (6-month-old) entire brains from a family of heterozygous mutant and wild type sibling fish. Gene ontology (GO) analysis revealed effects on mitochondria, particularly ATP synthesis, and on ATP-dependent processes including vacuolar acidification.

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Posted February 06, 2019.
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A familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene affects brain energy production
Morgan Newman, Nhi Hin, Stephen M Pederson, Michael Lardelli
bioRxiv 542134; doi: https://doi.org/10.1101/542134
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A familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene affects brain energy production
Morgan Newman, Nhi Hin, Stephen M Pederson, Michael Lardelli
bioRxiv 542134; doi: https://doi.org/10.1101/542134

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