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Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory

Brianna Vandrey, Derek L. F. Garden, Veronika Ambrozova, Christina McClure, Matthew F. Nolan, View ORCID ProfileJames A. Ainge
doi: https://doi.org/10.1101/543777
Brianna Vandrey
1Centre for Discovery Brain Sciences, University of Edinburgh
2School of Psychology & Neuroscience, University of St Andrews
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Derek L. F. Garden
1Centre for Discovery Brain Sciences, University of Edinburgh
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Veronika Ambrozova
2School of Psychology & Neuroscience, University of St Andrews
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Christina McClure
1Centre for Discovery Brain Sciences, University of Edinburgh
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Matthew F. Nolan
1Centre for Discovery Brain Sciences, University of Edinburgh
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  • For correspondence: matt.nolan@ed.ac.uk jaa7@st-andrews.ac.uk
James A. Ainge
2School of Psychology & Neuroscience, University of St Andrews
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  • ORCID record for James A. Ainge
  • For correspondence: matt.nolan@ed.ac.uk jaa7@st-andrews.ac.uk
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Abstract

The lateral entorhinal cortex (LEC) is a critical structure for episodic memory, but the roles of discrete neuronal populations within LEC are unclear. Here, we establish an approach for selectively targeting fan cells in layer 2 (L2) of LEC. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory, we find that after selective suppression of synaptic output from fan cells mice still recognise novel object-context configurations, but are impaired in recognition of novel object-place-context associations. Our experiments suggest a segregation of memory functions within LEC networks and indicate that specific inactivation of fan cells leads to behavioural deficits reminiscent of early stages of Alzheimer’s disease.

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Posted February 11, 2019.
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Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
Brianna Vandrey, Derek L. F. Garden, Veronika Ambrozova, Christina McClure, Matthew F. Nolan, James A. Ainge
bioRxiv 543777; doi: https://doi.org/10.1101/543777
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Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
Brianna Vandrey, Derek L. F. Garden, Veronika Ambrozova, Christina McClure, Matthew F. Nolan, James A. Ainge
bioRxiv 543777; doi: https://doi.org/10.1101/543777

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