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Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy
View ORCID ProfileArtika P. Nath, Scott C. Ritchie, Nastasiya F. Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V. Ahola-Olli, Peter Würtz, Aki S. Havulinna, Kristiina Aalto, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T. Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
doi: https://doi.org/10.1101/544445
Artika P. Nath
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
2Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
3Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Scott C. Ritchie
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
2Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
Nastasiya F. Grinberg
4Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0SP, United Kingdom
Howard Ho-Fung Tang
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
Qin Qin Huang
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
5Department of Clinical Pathology, University of Melbourne, Parkville, VIC 3010, Australia
Shu Mei Teo
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
2Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
Ari V. Ahola-Olli
6Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland
7Satasairaala, Department of Internal Medicine, 28500 Pori, Finland
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland
Peter Würtz
9Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki 00290, Finland
10Nightingale Health Ltd, Helsinki 00300, Finland
Aki S. Havulinna
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland
11National Institute of Health and Welfare, Helsinki 00271, Finland
Kristiina Aalto
12Medicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland
Niina Pitkänen
6Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland
Terho Lehtimäki
13Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland
Mika Kähönen
14Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33521, Finland
Leo-Pekka Lyytikäinen
13Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland
Emma Raitoharju
13Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland
Ilkka Seppälä
13Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland
Antti-Pekka Sarin
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland
11National Institute of Health and Welfare, Helsinki 00271, Finland
Samuli Ripatti
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland
15Department of Public Health, University of Helsinki, Helsinki 00014, Finland
16Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Aarno Palotie
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland
16Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
17Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
18Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
19Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Markus Perola
8Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00014, Finland
11National Institute of Health and Welfare, Helsinki 00271, Finland
Jorma S Viikari
20Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku 20520, Finland
Sirpa Jalkanen
12Medicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland
Mikael Maksimow
12Medicity Research Laboratory, Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland
Marko Salmi
20Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku 20520, Finland
Chris Wallace
4Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0SP, United Kingdom
22MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, United Kingdom
Olli T. Raitakari
6Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland
23The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland
Veikko Salomaa
11National Institute of Health and Welfare, Helsinki 00271, Finland
Gad Abraham
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
2Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
5Department of Clinical Pathology, University of Melbourne, Parkville, VIC 3010, Australia
Johannes Kettunen
11National Institute of Health and Welfare, Helsinki 00271, Finland
24Computational Medicine, Centre for Life Course Health Research, University of Oulu, Oulu 90014, Finland
25NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland
26Biocenter Oulu, University of Oulu 90014, Finland
Michael Inouye
1Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
2Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
3Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
5Department of Clinical Pathology, University of Melbourne, Parkville, VIC 3010, Australia
27The Alan Turing Institute, London, United Kingdom
Posted February 08, 2019.
Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy
Artika P. Nath, Scott C. Ritchie, Nastasiya F. Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V. Ahola-Olli, Peter Würtz, Aki S. Havulinna, Kristiina Aalto, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T. Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
bioRxiv 544445; doi: https://doi.org/10.1101/544445
Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy
Artika P. Nath, Scott C. Ritchie, Nastasiya F. Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V. Ahola-Olli, Peter Würtz, Aki S. Havulinna, Kristiina Aalto, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T. Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
bioRxiv 544445; doi: https://doi.org/10.1101/544445
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