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Hippocampal Activity Dynamics During Contextual Reward Association in Virtual Reality Place Conditioning

Sidney B. Williams, Moises Arriaga, William W. Post, Akshata A. Korgaonkar, Jose A. Morón, Edward B. Han
doi: https://doi.org/10.1101/545608
Sidney B. Williams
1Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA
2Pain Center, Washington University School of Medicine, St. Louis, MO, USA
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Moises Arriaga
3Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA
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William W. Post
1Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA
2Pain Center, Washington University School of Medicine, St. Louis, MO, USA
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Akshata A. Korgaonkar
3Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA
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Jose A. Morón
1Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA
2Pain Center, Washington University School of Medicine, St. Louis, MO, USA
4Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
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  • For correspondence: jmoron-concepcion@wustl.edu ehan23@wustl.edu
Edward B. Han
3Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA
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  • For correspondence: jmoron-concepcion@wustl.edu ehan23@wustl.edu
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ABSTRACT

Exposure to environmental contexts associated with drug use can induce cravings that promote continued use and/or relapse. Opioid abuse is marked by high relapse rates, suggesting that contextual memories formed during opioid use may be particularly strong. While it is known that reward-seeking behavior is controlled by the mesolimbic reward circuit, little is understood about how contextual memories are altered by drug use. The dorsal hippocampus (dHPC) is necessary for multiple types of contextual learning and the place-specific activity of CA1 place cells map out space in a given environment. Here we examined the neuronal representation of context as animals developed morphine-paired environmental associations using a conditioned place preference (CPP) paradigm. To investigate changes in the hippocampal encoding before, during, and after drug-pairing, we developed a virtual reality (VR) morphine CPP (Mor-CPP) paradigm and used in vivo two-photon calcium imaging to record the activity of CA1 pyramidal neurons. We found increased activity in rewarded contexts following real-time operant conditioning with water rewards, but not after Mor-CPP training, suggesting different neural encoding mechanisms for natural reinforcers and morphine.

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Posted February 10, 2019.
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Hippocampal Activity Dynamics During Contextual Reward Association in Virtual Reality Place Conditioning
Sidney B. Williams, Moises Arriaga, William W. Post, Akshata A. Korgaonkar, Jose A. Morón, Edward B. Han
bioRxiv 545608; doi: https://doi.org/10.1101/545608
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Hippocampal Activity Dynamics During Contextual Reward Association in Virtual Reality Place Conditioning
Sidney B. Williams, Moises Arriaga, William W. Post, Akshata A. Korgaonkar, Jose A. Morón, Edward B. Han
bioRxiv 545608; doi: https://doi.org/10.1101/545608

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