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Predictive neural processing in adult zebrafish depends on shank3b

Kuo-Hua Huang, Peter Rupprecht, Michael Schebesta, Fabrizio Serluca, Kyohei Kitamura, Tewis Bouwmeester, Rainer W Friedrich
doi: https://doi.org/10.1101/546457
Kuo-Hua Huang
Friedrich Miescher Institute for Biomedical Research;
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  • For correspondence: kuo-hua.huang@fmi.ch
Peter Rupprecht
Friedrich Miescher Institute for Biomedical Research;
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  • For correspondence: peter.rupprecht@fmi.ch
Michael Schebesta
Novartis Institutes for Biomedical Research
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Fabrizio Serluca
Novartis Institutes for Biomedical Research
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Kyohei Kitamura
Friedrich Miescher Institute for Biomedical Research;
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Tewis Bouwmeester
Novartis Institutes for Biomedical Research
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Rainer W Friedrich
Friedrich Miescher Institute for Biomedical Research;
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  • For correspondence: rainer.friedrich@fmi.ch
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Abstract

Intelligent behavior requires a comparison between the predicted and the actual consequences of behavioral actions. According to the theory of predictive processing, this comparison relies on a neuronal error signal that reflects the mismatch between an internal prediction and sensory input. Inappropriate error signals may generate pathological experiences in neuropsychiatric conditions. To examine the processing of sensorimotor prediction errors across different telencephalic brain areas we optically measured neuronal activity in head-fixed, adult zebrafish in a virtual reality. Brief perturbations of visuomotor feedback triggered distinct changes in swimming behavior and different neuronal responses. Neuronal activity reflecting sensorimotor mismatch, rather than sensory input or motor output alone, was prominent throughout multiple forebrain areas. This activity preceded and predicted the transition in motor behavior. Error signals were altered in specific forebrain regions by a mutation in the autism-related gene shank3b. Predictive processing is therefore a widespread phenomenon that may contribute to disease phenotypes.

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Posted February 11, 2019.
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Predictive neural processing in adult zebrafish depends on shank3b
Kuo-Hua Huang, Peter Rupprecht, Michael Schebesta, Fabrizio Serluca, Kyohei Kitamura, Tewis Bouwmeester, Rainer W Friedrich
bioRxiv 546457; doi: https://doi.org/10.1101/546457
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Predictive neural processing in adult zebrafish depends on shank3b
Kuo-Hua Huang, Peter Rupprecht, Michael Schebesta, Fabrizio Serluca, Kyohei Kitamura, Tewis Bouwmeester, Rainer W Friedrich
bioRxiv 546457; doi: https://doi.org/10.1101/546457

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