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Model ensembles with different response variables for base and meta models: malaria disaggregation regression combining prevalence and incidence data

View ORCID ProfileTim C. D. Lucas, Anita Nandi, Michele Nguyen, Susan Rumisha, Katherine E. Battle, Rosalind E. Howes, Chantal Hendriks, Andre Python, Penny Hancock, Ewan Cameron, Pete Gething, Daniel J. Weiss
doi: https://doi.org/10.1101/548719
Tim C. D. Lucas
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • ORCID record for Tim C. D. Lucas
  • For correspondence: timcdlucas@gmail.com
Anita Nandi
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Michele Nguyen
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Susan Rumisha
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Katherine E. Battle
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Rosalind E. Howes
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Chantal Hendriks
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Andre Python
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Penny Hancock
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Ewan Cameron
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
Pete Gething
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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Daniel J. Weiss
1Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, UK -
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  • For correspondence: timcdlucas@gmail.com
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Abstract

Maps of infection risk are a vital tool for the elimination of malaria. Routine surveillance data of malaria case counts, often aggregated over administrative regions, is becoming more widely available and can better measure low malaria risk than prevalence surveys. However, aggregation of case counts over large, heterogeneous areas means that these data are often underpowered for learning relationships between the environment and malaria risk. A model that combines point surveys and aggregated surveillance data could have the benefits of both but must be able to account for the fact that these two data types are different malariometric units. Here, we train multiple machine learning models on point surveys and then combine the predictions from these with a geostatistical disaggregation model that uses routine surveillance data. We find that, in tests using data from Colombia and Madagascar, using a disaggregation regression model to combine predictions from machine learning models trained on point surveys improves model accuracy relative to using the environmental covariates directly.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 15, 2019.
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Model ensembles with different response variables for base and meta models: malaria disaggregation regression combining prevalence and incidence data
Tim C. D. Lucas, Anita Nandi, Michele Nguyen, Susan Rumisha, Katherine E. Battle, Rosalind E. Howes, Chantal Hendriks, Andre Python, Penny Hancock, Ewan Cameron, Pete Gething, Daniel J. Weiss
bioRxiv 548719; doi: https://doi.org/10.1101/548719
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Model ensembles with different response variables for base and meta models: malaria disaggregation regression combining prevalence and incidence data
Tim C. D. Lucas, Anita Nandi, Michele Nguyen, Susan Rumisha, Katherine E. Battle, Rosalind E. Howes, Chantal Hendriks, Andre Python, Penny Hancock, Ewan Cameron, Pete Gething, Daniel J. Weiss
bioRxiv 548719; doi: https://doi.org/10.1101/548719

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