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A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans

View ORCID ProfileLuis R. Saraiva, View ORCID ProfileFernando Riveros-McKay, Massimo Mezzavilla, Eman H. Abou-Moussa, Charles J. Arayata, Casey Trimmer, View ORCID ProfileXimena Ibarra-Soria, Mona Khan, Laura Van Gerven, Mark Jorissen, Matthew Gibbs, Ciaran O’Flynn, Scott McGrane, Peter Mombaerts, John C. Marioni, Joel D. Mainland, Darren W. Logan
doi: https://doi.org/10.1101/552232
Luis R. Saraiva
1Sidra Medicine, PO Box 26999, Doha, Qatar
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
3European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
4Monell Chemical Senses Center, Philadelphia, PA 19104, USA
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  • ORCID record for Luis R. Saraiva
  • For correspondence: saraivalmr@gmail.com darren.logan@effem.com
Fernando Riveros-McKay
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
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Massimo Mezzavilla
1Sidra Medicine, PO Box 26999, Doha, Qatar
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Eman H. Abou-Moussa
1Sidra Medicine, PO Box 26999, Doha, Qatar
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Charles J. Arayata
4Monell Chemical Senses Center, Philadelphia, PA 19104, USA
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Casey Trimmer
4Monell Chemical Senses Center, Philadelphia, PA 19104, USA
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Ximena Ibarra-Soria
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
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  • ORCID record for Ximena Ibarra-Soria
Mona Khan
5Max Planck Research Unit for Neurogenetics, Max von-Laue-Strasse 4, 60438 Frankfurt, Germany
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Laura Van Gerven
6Department of ENT-HNS, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
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Mark Jorissen
6Department of ENT-HNS, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
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Matthew Gibbs
7Waltham Centre for Pet Nutrition, Leicestershire, LE14 4RT, UK
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Ciaran O’Flynn
7Waltham Centre for Pet Nutrition, Leicestershire, LE14 4RT, UK
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Scott McGrane
7Waltham Centre for Pet Nutrition, Leicestershire, LE14 4RT, UK
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Peter Mombaerts
5Max Planck Research Unit for Neurogenetics, Max von-Laue-Strasse 4, 60438 Frankfurt, Germany
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John C. Marioni
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
3European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
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Joel D. Mainland
4Monell Chemical Senses Center, Philadelphia, PA 19104, USA
8Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, 19104, USA
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Darren W. Logan
2Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton-Cambridge, CB10 1SD, United Kingdom
4Monell Chemical Senses Center, Philadelphia, PA 19104, USA
7Waltham Centre for Pet Nutrition, Leicestershire, LE14 4RT, UK
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  • For correspondence: saraivalmr@gmail.com darren.logan@effem.com
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ABSTRACT

The mammalian olfactory system displays species-specific adaptations to different ecological niches. To investigate the evolutionary dynamics of olfactory sensory neuron (OSN) sub-types across 95 million years of mammalian evolution, we applied RNA-sequencing of whole olfactory mucosa samples from mouse, rat, dog, marmoset, macaque and human. We find that OSN subtypes representative of all known mouse chemosensory receptor gene families are present in all analyzed species. Further, we show that OSN subtypes expressing canonical olfactory receptors (ORs) are distributed across a large dynamic range and that homologous subtypes can be either highly abundant across all species or species/order-specific. Interestingly, highly abundant mouse and human OSN subtypes detect odorants with similar sensory profiles, and sense ecologically relevant odorants, such as mouse semiochemicals or human key food odorants. Taken together, our results allow for a better understanding of the evolution of mammalian olfaction in mammals and provide insights into the possible functions of highly abundant OSN subtypes in mouse and human.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 16, 2019.
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A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
Luis R. Saraiva, Fernando Riveros-McKay, Massimo Mezzavilla, Eman H. Abou-Moussa, Charles J. Arayata, Casey Trimmer, Ximena Ibarra-Soria, Mona Khan, Laura Van Gerven, Mark Jorissen, Matthew Gibbs, Ciaran O’Flynn, Scott McGrane, Peter Mombaerts, John C. Marioni, Joel D. Mainland, Darren W. Logan
bioRxiv 552232; doi: https://doi.org/10.1101/552232
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A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
Luis R. Saraiva, Fernando Riveros-McKay, Massimo Mezzavilla, Eman H. Abou-Moussa, Charles J. Arayata, Casey Trimmer, Ximena Ibarra-Soria, Mona Khan, Laura Van Gerven, Mark Jorissen, Matthew Gibbs, Ciaran O’Flynn, Scott McGrane, Peter Mombaerts, John C. Marioni, Joel D. Mainland, Darren W. Logan
bioRxiv 552232; doi: https://doi.org/10.1101/552232

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