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Discovery of conformation-sensitive anti-amyloid protofibril monoclonal antibodies using an engineered chaperone-like amyloid-binding protein
View ORCID ProfileW Vallen Graham, Alessandra Bonito-Oliva, Rita Agostinelli, Riyaz Karim, Jeremy Deguzman, Kerry Kelleher, Marianne Petro, Anna-Karin Lindström, Caroline Graff, Kathleen M. Wood, Lioudmila Tchistiakova, Kimberly Marquette, Paul D. Wes, Thomas P. Sakmar
doi: https://doi.org/10.1101/558809
W Vallen Graham
1Laboratory of Chemical Biology & Signal Transduction, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Alessandra Bonito-Oliva
1Laboratory of Chemical Biology & Signal Transduction, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Rita Agostinelli
2Biomedicine Design, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA
Riyaz Karim
2Biomedicine Design, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA
Jeremy Deguzman
3Centers for Therapeutic Innovation, Pfizer, 450 E 29th Street, New York, NY 10016, USA
Kerry Kelleher
2Biomedicine Design, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA
Marianne Petro
4Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 14157 Huddinge, Sweden
Anna-Karin Lindström
4Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 14157 Huddinge, Sweden
Caroline Graff
4Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 14157 Huddinge, Sweden
5Theme Aging, Genetics Unit, Karolinska University Hospital-Huddinge, 141 86 Stockholm, Sweden
Kathleen M. Wood
6Neuroscience and Pain Research Unit, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge MA 02139, USA
Lioudmila Tchistiakova
2Biomedicine Design, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA
Kimberly Marquette
2Biomedicine Design, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA
Paul D. Wes
3Centers for Therapeutic Innovation, Pfizer, 450 E 29th Street, New York, NY 10016, USA
Thomas P. Sakmar
1Laboratory of Chemical Biology & Signal Transduction, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
4Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 14157 Huddinge, Sweden
Posted February 24, 2019.
Discovery of conformation-sensitive anti-amyloid protofibril monoclonal antibodies using an engineered chaperone-like amyloid-binding protein
W Vallen Graham, Alessandra Bonito-Oliva, Rita Agostinelli, Riyaz Karim, Jeremy Deguzman, Kerry Kelleher, Marianne Petro, Anna-Karin Lindström, Caroline Graff, Kathleen M. Wood, Lioudmila Tchistiakova, Kimberly Marquette, Paul D. Wes, Thomas P. Sakmar
bioRxiv 558809; doi: https://doi.org/10.1101/558809
Discovery of conformation-sensitive anti-amyloid protofibril monoclonal antibodies using an engineered chaperone-like amyloid-binding protein
W Vallen Graham, Alessandra Bonito-Oliva, Rita Agostinelli, Riyaz Karim, Jeremy Deguzman, Kerry Kelleher, Marianne Petro, Anna-Karin Lindström, Caroline Graff, Kathleen M. Wood, Lioudmila Tchistiakova, Kimberly Marquette, Paul D. Wes, Thomas P. Sakmar
bioRxiv 558809; doi: https://doi.org/10.1101/558809
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