New Results
Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile
Raymond Noordam, Maxime M Bos, Heming Wang, Thomas W Winkler, Amy R Bentley, Tuomas O. Kilpeläinen, Paul S de Vries, Yun Ju Sung, Karen Schwander, Brian E Cade, Alisa Manning, Hugues Aschard, Michael R Brown, Han Chen, Nora Franceschini, Solomon K Musani, Melissa Richard, Dina Vojinovic, Stella Aslibekyan, Traci M Bartz, Lisa de las Fuentes, Mary Feitosa, Andrea R Horimoto, Marjan Ilkov, Minjung Kho, Aldi Kraja, Changwei Li, Elise Lim, Yongmei Liu, Dennis O Mook-Kanamori, Tuomo Rankinen, Salman M Tajuddin, Ashley van der Spek, Zhe Wang, Jonathan Marten, Vincent Laville, Maris Alver, Evangelos Evangelou, Maria E Graff, Meian He, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Pedro Marques-Vidal, Ilja M Nolte, Nicholette D Palmer, Rainer Rauramaa, Xiao-Ou Shu, Harold Snieder, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Correa Adolfo, Christie Ballantyne, Larry Bielak, Nienke R Biermasz, Eric Boerwinkle, Niki Dimou, Gudny Eiriksdottir, Chuan Gao, Sina A Gharib, Daniel J Gottlieb, José Haba-Rubio, Tamara B Harris, Sami Heikkinen, Raphaël Heinzer, James E Hixson, Georg Homuth, M Arfan Ikram, Pirjo Komulainen, Jose E Krieger, Jiwon Lee, Jingmin Liu, Kurt K Lohman, Annemarie I Luik, Reedik Mägi, Lisa W Martin, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Mike A Nalls, Jeff O’Connell, Annette Peters, Patricia Peyser, Olli T Raitakari, Alex P Reiner, Patrick CN Rensen, Treva K Rice, Stephen S Rich, Till Roenneberg, Jerome I Rotter, Pamela J Schreiner, James Shikany, Stephen S Sidney, Mario Sims, Colleen M Sitlani, Tamar Sofer, Konstantin Strauch, Morris A Swertz, Kent D Taylor, André G Uitterlinden, Cornelia M van Duijn, Henry Völzke, Melanie Waldenberger, Robert B Wallance, Ko Willems van Dijk, Caizheng Yu, Alan B Zonderman, Diane M Becker, Paul Elliott, Tõnu Esko, Christian Gieger, Hans J Grabe, Timo A Lakka, Terho Lehtimäki, Lifelines Cohort Study, Kari E North, Brenda WJH Penninx, Peter Vollenweider, Lynne E Wagenknecht, Tangchun Wu, Yong-Bing Xiang, Wei Zheng, Donna K Arnett, Claude Bouchard, Michele K Evans, Vilmundur Gudnason, Sharon Kardia, Tanika N Kelly, Stephen B Kritchevsky, Ruth JF Loos, Alexandre C Pereira, Mike Province, Bruce M Psaty, Charles Rotimi, Xiaofeng Zhu, Najaf Amin, L Adrienne Cupples, Myriam Fornage, Ervin F Fox, Xiuqing Guo, W James Gauderman, Kenneth Rice, Charles Kooperberg, Patricia B Munroe, Ching-Ti Liu, Alanna C Morrison, Dabeeru C Rao, Diana van Heemst, Susan Redline
doi: https://doi.org/10.1101/559393
Raymond Noordam
1Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Maxime M Bos
1Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Heming Wang
2Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
Thomas W Winkler
3Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Amy R Bentley
4Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Tuomas O. Kilpeläinen
5Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
6Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paul S de Vries
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Yun Ju Sung
8Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Karen Schwander
8Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Brian E Cade
2Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
Alisa Manning
9Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
10Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Hugues Aschard
11Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
12Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.
Michael R Brown
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Han Chen
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
13Center for Precision Health, School of Public Health & School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Nora Franceschini
14Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Solomon K Musani
15Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Melissa Richard
16Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Dina Vojinovic
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stella Aslibekyan
18Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Traci M Bartz
19Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington, USA.
Lisa de las Fuentes
20Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
8Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Mary Feitosa
21Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Andrea R Horimoto
22Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Marjan Ilkov
23Icelandic Heart Association, Kopavogur, Iceland.
Minjung Kho
24Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Aldi Kraja
21Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Changwei Li
25Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia, USA.
Elise Lim
26Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Yongmei Liu
27Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Dennis O Mook-Kanamori
28Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
29Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Leiden.
Tuomo Rankinen
30Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Salman M Tajuddin
31Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Ashley van der Spek
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Zhe Wang
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jonathan Marten
32Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Vincent Laville
12Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.
Maris Alver
33Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
34Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Evangelos Evangelou
35Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
36Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Maria E Graff
14Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Meian He
37Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Brigitte Kühnel
38Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
39Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Leo-Pekka Lyytikäinen
40Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
41Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Technology, Tampere University, Tampere, Finland.
Pedro Marques-Vidal
42Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Ilja M Nolte
43University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Nicholette D Palmer
44Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Rainer Rauramaa
45Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Xiao-Ou Shu
46Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Harold Snieder
43University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Stefan Weiss
47Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Wanqing Wen
46Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Lisa R Yanek
48Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Correa Adolfo
15Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Christie Ballantyne
49Section of Cardiovascular Research, Baylor College of Medicine, Houston, Texas, USA.
50Houston Methodist Debakey Heart and Vascular Center, Houston, Texas, USA.
Larry Bielak
24Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Nienke R Biermasz
51Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands, and Einthoven Laboratory for Experimental Vascular Medicine.
Eric Boerwinkle
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
52Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
Niki Dimou
36Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Gudny Eiriksdottir
23Icelandic Heart Association, Kopavogur, Iceland.
Chuan Gao
53Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Sina A Gharib
54Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Medicine, University of Washington, Seattle, Washington, USA.
Daniel J Gottlieb
10Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
2Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
55VA Boston Healthcare System, Boston, MA, USA
José Haba-Rubio
56Medicine, Sleep Laboratory, Lausanne University Hospital, Lausanne, Switzerland.
Tamara B Harris
57Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Sami Heikkinen
58Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
95Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.
Raphaël Heinzer
56Medicine, Sleep Laboratory, Lausanne University Hospital, Lausanne, Switzerland.
James E Hixson
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Georg Homuth
47Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
M Arfan Ikram
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
59Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Pirjo Komulainen
45Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Jose E Krieger
22Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Jiwon Lee
2Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
Jingmin Liu
60Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington, USA.
Kurt K Lohman
61Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA.
Annemarie I Luik
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Reedik Mägi
33Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lisa W Martin
62Cardiology, School of Medicine and Health Sciences, George Washington University, Washington D.C., USA.
Thomas Meitinger
63Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andres Metspalu
33Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
34Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Yuri Milaneschi
62Cardiology, School of Medicine and Health Sciences, George Washington University, Washington D.C., USA.
Mike A Nalls
65Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.
66Data Tecnica International, Glen Echo, Maryland, USA.
Jeff O’Connell
67Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
68Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Annette Peters
39Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
69DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany.
Patricia Peyser
24Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Olli T Raitakari
70Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
71University of Turku, Turku, Finland.
Alex P Reiner
60Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington, USA.
Patrick CN Rensen
51Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands, and Einthoven Laboratory for Experimental Vascular Medicine.
Treva K Rice
8Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Stephen S Rich
72Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Till Roenneberg
73Institute of Medical Psychology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
Jerome I Rotter
74Genomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Pamela J Schreiner
75Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
James Shikany
76Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Stephen S Sidney
77Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Mario Sims
15Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Colleen M Sitlani
78Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington, USA.
Tamar Sofer
2Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
79Institute of Human Genetics, Technische Universität München, Munich, Germany.
Konstantin Strauch
80Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
81Institute for Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
Morris A Swertz
82University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Kent D Taylor
74Genomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
André G Uitterlinden
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
83Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Cornelia M van Duijn
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
84Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Henry Völzke
85Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Melanie Waldenberger
38Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
39Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
69DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany.
Robert B Wallance
86Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USA.
Ko Willems van Dijk
51Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands, and Einthoven Laboratory for Experimental Vascular Medicine.
87Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Caizheng Yu
37Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Alan B Zonderman
88Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Diane M Becker
48Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Paul Elliott
34Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
89MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
90National Institute of Health Research Imperial College London Biomedical Research Centre, London, UK
91UK-DRI Dementia Research Institute at Imperial College London, London, UK
Tõnu Esko
33Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
92Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA.
Christian Gieger
38Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
93German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Hans J Grabe
94Department Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Timo A Lakka
45Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
95Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.
96Department of Clinical Phsiology and Nuclear Medicine, Kuopia University Hospital, Kuopio, Finland
Terho Lehtimäki
40Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
41Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Technology, Tampere University, Tampere, Finland.
Lifelines Cohort Study
97Lifelines Cohort, Groningen, The Netherlands.
Kari E North
14Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Brenda WJH Penninx
64Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Peter Vollenweider
42Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Lynne E Wagenknecht
98Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Tangchun Wu
37Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yong-Bing Xiang
99SKLORG & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
Wei Zheng
46Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Donna K Arnett
100Dean’s Office, University of Kentucky College of Public Health, Lexington, Kentucky, USA.
Claude Bouchard
30Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Michele K Evans
31Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Vilmundur Gudnason
23Icelandic Heart Association, Kopavogur, Iceland.
101Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Sharon Kardia
24Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Tanika N Kelly
102Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Stephen B Kritchevsky
103Sticht Center for Healthy Aging and Rehabilitation, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Ruth JF Loos
104The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
105The Mindich Child Health Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Alexandre C Pereira
22Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Mike Province
21Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Bruce M Psaty
106Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, USA.
107Kaiser Permanente Washington, Health Research Institute, Seattle, Washington, USA.
Charles Rotimi
4Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Xiaofeng Zhu
108Department of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Najaf Amin
17Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
L Adrienne Cupples
26Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
109NHLBI Framingham Heart Study, Framingham, Massachusetts, USA.
Myriam Fornage
16Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ervin F Fox
110Cardiology, Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Xiuqing Guo
74Genomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
W James Gauderman
111Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Kenneth Rice
112Department of Biostatistics, University of Washington, Seattle, Washington, USA.
Charles Kooperberg
60Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington, USA.
Patricia B Munroe
113Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
114NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, London, UK.
Ching-Ti Liu
26Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Alanna C Morrison
7Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Dabeeru C Rao
8Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Diana van Heemst
1Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Susan Redline
2Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
115Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Abstract
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To provide new insights in the biology of sleep-associated adverse lipid profile, we conducted multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identified 49 novel lipid loci, and 10 additional novel lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identified new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The novel gene-sleep interactions had a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explained 4.25% of the variance in triglyceride concentration. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted February 25, 2019.
Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile
Raymond Noordam, Maxime M Bos, Heming Wang, Thomas W Winkler, Amy R Bentley, Tuomas O. Kilpeläinen, Paul S de Vries, Yun Ju Sung, Karen Schwander, Brian E Cade, Alisa Manning, Hugues Aschard, Michael R Brown, Han Chen, Nora Franceschini, Solomon K Musani, Melissa Richard, Dina Vojinovic, Stella Aslibekyan, Traci M Bartz, Lisa de las Fuentes, Mary Feitosa, Andrea R Horimoto, Marjan Ilkov, Minjung Kho, Aldi Kraja, Changwei Li, Elise Lim, Yongmei Liu, Dennis O Mook-Kanamori, Tuomo Rankinen, Salman M Tajuddin, Ashley van der Spek, Zhe Wang, Jonathan Marten, Vincent Laville, Maris Alver, Evangelos Evangelou, Maria E Graff, Meian He, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Pedro Marques-Vidal, Ilja M Nolte, Nicholette D Palmer, Rainer Rauramaa, Xiao-Ou Shu, Harold Snieder, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Correa Adolfo, Christie Ballantyne, Larry Bielak, Nienke R Biermasz, Eric Boerwinkle, Niki Dimou, Gudny Eiriksdottir, Chuan Gao, Sina A Gharib, Daniel J Gottlieb, José Haba-Rubio, Tamara B Harris, Sami Heikkinen, Raphaël Heinzer, James E Hixson, Georg Homuth, M Arfan Ikram, Pirjo Komulainen, Jose E Krieger, Jiwon Lee, Jingmin Liu, Kurt K Lohman, Annemarie I Luik, Reedik Mägi, Lisa W Martin, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Mike A Nalls, Jeff O’Connell, Annette Peters, Patricia Peyser, Olli T Raitakari, Alex P Reiner, Patrick CN Rensen, Treva K Rice, Stephen S Rich, Till Roenneberg, Jerome I Rotter, Pamela J Schreiner, James Shikany, Stephen S Sidney, Mario Sims, Colleen M Sitlani, Tamar Sofer, Konstantin Strauch, Morris A Swertz, Kent D Taylor, André G Uitterlinden, Cornelia M van Duijn, Henry Völzke, Melanie Waldenberger, Robert B Wallance, Ko Willems van Dijk, Caizheng Yu, Alan B Zonderman, Diane M Becker, Paul Elliott, Tõnu Esko, Christian Gieger, Hans J Grabe, Timo A Lakka, Terho Lehtimäki, Lifelines Cohort Study, Kari E North, Brenda WJH Penninx, Peter Vollenweider, Lynne E Wagenknecht, Tangchun Wu, Yong-Bing Xiang, Wei Zheng, Donna K Arnett, Claude Bouchard, Michele K Evans, Vilmundur Gudnason, Sharon Kardia, Tanika N Kelly, Stephen B Kritchevsky, Ruth JF Loos, Alexandre C Pereira, Mike Province, Bruce M Psaty, Charles Rotimi, Xiaofeng Zhu, Najaf Amin, L Adrienne Cupples, Myriam Fornage, Ervin F Fox, Xiuqing Guo, W James Gauderman, Kenneth Rice, Charles Kooperberg, Patricia B Munroe, Ching-Ti Liu, Alanna C Morrison, Dabeeru C Rao, Diana van Heemst, Susan Redline
bioRxiv 559393; doi: https://doi.org/10.1101/559393
Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile
Raymond Noordam, Maxime M Bos, Heming Wang, Thomas W Winkler, Amy R Bentley, Tuomas O. Kilpeläinen, Paul S de Vries, Yun Ju Sung, Karen Schwander, Brian E Cade, Alisa Manning, Hugues Aschard, Michael R Brown, Han Chen, Nora Franceschini, Solomon K Musani, Melissa Richard, Dina Vojinovic, Stella Aslibekyan, Traci M Bartz, Lisa de las Fuentes, Mary Feitosa, Andrea R Horimoto, Marjan Ilkov, Minjung Kho, Aldi Kraja, Changwei Li, Elise Lim, Yongmei Liu, Dennis O Mook-Kanamori, Tuomo Rankinen, Salman M Tajuddin, Ashley van der Spek, Zhe Wang, Jonathan Marten, Vincent Laville, Maris Alver, Evangelos Evangelou, Maria E Graff, Meian He, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Pedro Marques-Vidal, Ilja M Nolte, Nicholette D Palmer, Rainer Rauramaa, Xiao-Ou Shu, Harold Snieder, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Correa Adolfo, Christie Ballantyne, Larry Bielak, Nienke R Biermasz, Eric Boerwinkle, Niki Dimou, Gudny Eiriksdottir, Chuan Gao, Sina A Gharib, Daniel J Gottlieb, José Haba-Rubio, Tamara B Harris, Sami Heikkinen, Raphaël Heinzer, James E Hixson, Georg Homuth, M Arfan Ikram, Pirjo Komulainen, Jose E Krieger, Jiwon Lee, Jingmin Liu, Kurt K Lohman, Annemarie I Luik, Reedik Mägi, Lisa W Martin, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Mike A Nalls, Jeff O’Connell, Annette Peters, Patricia Peyser, Olli T Raitakari, Alex P Reiner, Patrick CN Rensen, Treva K Rice, Stephen S Rich, Till Roenneberg, Jerome I Rotter, Pamela J Schreiner, James Shikany, Stephen S Sidney, Mario Sims, Colleen M Sitlani, Tamar Sofer, Konstantin Strauch, Morris A Swertz, Kent D Taylor, André G Uitterlinden, Cornelia M van Duijn, Henry Völzke, Melanie Waldenberger, Robert B Wallance, Ko Willems van Dijk, Caizheng Yu, Alan B Zonderman, Diane M Becker, Paul Elliott, Tõnu Esko, Christian Gieger, Hans J Grabe, Timo A Lakka, Terho Lehtimäki, Lifelines Cohort Study, Kari E North, Brenda WJH Penninx, Peter Vollenweider, Lynne E Wagenknecht, Tangchun Wu, Yong-Bing Xiang, Wei Zheng, Donna K Arnett, Claude Bouchard, Michele K Evans, Vilmundur Gudnason, Sharon Kardia, Tanika N Kelly, Stephen B Kritchevsky, Ruth JF Loos, Alexandre C Pereira, Mike Province, Bruce M Psaty, Charles Rotimi, Xiaofeng Zhu, Najaf Amin, L Adrienne Cupples, Myriam Fornage, Ervin F Fox, Xiuqing Guo, W James Gauderman, Kenneth Rice, Charles Kooperberg, Patricia B Munroe, Ching-Ti Liu, Alanna C Morrison, Dabeeru C Rao, Diana van Heemst, Susan Redline
bioRxiv 559393; doi: https://doi.org/10.1101/559393
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