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Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks

Elizabeth J. Brant, Edward A. Rietman, Giannoula Lakka Klement, Marco Cavaglia, Jack A. Tuszynski
doi: https://doi.org/10.1101/559740
Elizabeth J. Brant
1Nephrology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
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Edward A. Rietman
2BINDS lab, College of Information and Computer Sciences, University of Massachusetts Amherst, MA 01003, USA
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Giannoula Lakka Klement
3CSTS, Toronto, Ontario, Canada
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Marco Cavaglia
4ACTISMED, srl, Torino, Italy
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Jack A. Tuszynski
5DIMEAS, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, 10129, Italy
6Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada
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  • For correspondence: jackt@ualberta.ca
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Abstract

We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associated protein-protein interaction networks for each of the 291 patients whose samples were used to provide the molecular data. We have concluded that among the many proteins that appear to play critical roles in this pathology, most of them are either ribosomal proteins, ubiquitination pathway proteins or heat shock proteins. We propose some of the proteins identified in this study to be considered for drug targeting.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 24, 2019.
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Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks
Elizabeth J. Brant, Edward A. Rietman, Giannoula Lakka Klement, Marco Cavaglia, Jack A. Tuszynski
bioRxiv 559740; doi: https://doi.org/10.1101/559740
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Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks
Elizabeth J. Brant, Edward A. Rietman, Giannoula Lakka Klement, Marco Cavaglia, Jack A. Tuszynski
bioRxiv 559740; doi: https://doi.org/10.1101/559740

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