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A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population
View ORCID ProfileSamira Asgari, Yang Luo, Gillian M. Belbin, Eric Bartell, Roger Calderon, Kamil Slowikowski, Carmen Contreras, Rosa Yataco, Jerome T. Galea, Judith Jimenez, Julia M. Coit, Chandel Farroñay, Rosalynn M. Nazarian, Timothy D. O’Connor, Harry C. Dietz, Joel Hirschhorn, Heinner Guio, Leonid Lecca, Eimear E. Kenny, Esther Freeman, Megan B. Murray, Soumya Raychaudhuri
doi: https://doi.org/10.1101/561241
Samira Asgari
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Yang Luo
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Gillian M. Belbin
5The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY
6The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
7Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
8Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Eric Bartell
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA
Roger Calderon
10Socios En Salud, Lima, Perú
Kamil Slowikowski
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Carmen Contreras
10Socios En Salud, Lima, Perú
Rosa Yataco
10Socios En Salud, Lima, Perú
Jerome T. Galea
11School of Social Work, University of South Florida, Tampa, FL
Judith Jimenez
10Socios En Salud, Lima, Perú
Julia M. Coit
12Department of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Chandel Farroñay
10Socios En Salud, Lima, Perú
Rosalynn M. Nazarian
13Massachusetts General Hospital, Division of Nephrology, Department of Medicine, Boston, Massachusetts
Timothy D. O’Connor
14Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, USA
Harry C. Dietz
15Howard Hughes Medical Institute, Bethesda, Maryland, USA
Joel Hirschhorn
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA
Heinner Guio
16Instituto Nacional de Salud, Lima, Perú
Leonid Lecca
7Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
Eimear E. Kenny
5The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY
6The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
7Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
8Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Esther Freeman
17Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, USA
Megan B. Murray
12Department of Global Health and Social Medicine, and Division of Global Health Equity, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Soumya Raychaudhuri
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
2Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
18Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
Posted February 26, 2019.
A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population
Samira Asgari, Yang Luo, Gillian M. Belbin, Eric Bartell, Roger Calderon, Kamil Slowikowski, Carmen Contreras, Rosa Yataco, Jerome T. Galea, Judith Jimenez, Julia M. Coit, Chandel Farroñay, Rosalynn M. Nazarian, Timothy D. O’Connor, Harry C. Dietz, Joel Hirschhorn, Heinner Guio, Leonid Lecca, Eimear E. Kenny, Esther Freeman, Megan B. Murray, Soumya Raychaudhuri
bioRxiv 561241; doi: https://doi.org/10.1101/561241
A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population
Samira Asgari, Yang Luo, Gillian M. Belbin, Eric Bartell, Roger Calderon, Kamil Slowikowski, Carmen Contreras, Rosa Yataco, Jerome T. Galea, Judith Jimenez, Julia M. Coit, Chandel Farroñay, Rosalynn M. Nazarian, Timothy D. O’Connor, Harry C. Dietz, Joel Hirschhorn, Heinner Guio, Leonid Lecca, Eimear E. Kenny, Esther Freeman, Megan B. Murray, Soumya Raychaudhuri
bioRxiv 561241; doi: https://doi.org/10.1101/561241
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