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Two fiber pathways connecting amygdala and prefrontal cortex in humans and monkeys

View ORCID ProfileDavide Folloni, View ORCID ProfileJérôme Sallet, Alexandre A. Khrapitchev, Nicola R. Sibson, View ORCID ProfileLennart Verhagen, View ORCID ProfileRogier B. Mars
doi: https://doi.org/10.1101/561811
Davide Folloni
1Wellcome Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
2Wellcome Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
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  • For correspondence: davide.folloni@psy.ox.ac.uk
Jérôme Sallet
1Wellcome Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
2Wellcome Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
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Alexandre A. Khrapitchev
3Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Nicola R. Sibson
3Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom
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Lennart Verhagen
1Wellcome Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
2Wellcome Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
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Rogier B. Mars
2Wellcome Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
4Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
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Abstract

The interactions between amygdala and prefrontal cortex are pivotal to many neural processes involved in learning, decision-making, emotion, and social regulation. The broad functional role of amygdala-prefrontal interplay may reflect the diversity of its anatomical connections. Little, however, is known of the structural wiring linking amygdala and prefrontal cortex in humans. Using diffusion imaging techniques, we reconstructed connections between amygdala, anterior temporal and prefrontal cortex in human and macaque brains. First, by studying macaques we were able to assess which aspects of connectivity known from tracer studies could be identified with diffusion imaging. Second, by comparing diffusion imaging results in humans and macaques we were able to estimate amygdala-prefrontal connection patterns in humans and compare them with those in the monkey. We observed a prominent and well-preserved bifurcation of connections between amygdala and frontal lobe into two fiber networks – an amygdalofugal path and an uncinate fascicle path – in both species.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 20, 2019.
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Two fiber pathways connecting amygdala and prefrontal cortex in humans and monkeys
Davide Folloni, Jérôme Sallet, Alexandre A. Khrapitchev, Nicola R. Sibson, Lennart Verhagen, Rogier B. Mars
bioRxiv 561811; doi: https://doi.org/10.1101/561811
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Two fiber pathways connecting amygdala and prefrontal cortex in humans and monkeys
Davide Folloni, Jérôme Sallet, Alexandre A. Khrapitchev, Nicola R. Sibson, Lennart Verhagen, Rogier B. Mars
bioRxiv 561811; doi: https://doi.org/10.1101/561811

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